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Ecotoxicological information

Endpoint summary

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Additional information

For sulphamidic acid, three short term toxicity tests for aquatic toxicity have been conducted. They are all OECD guideline tests with GLP compliance, which focus on the short-term toxicity of sulphamidic acid to daphnia, algae and microorganisms in sludge respectively. In addition, a well-documented academic literature on short-term toxicity to fish has been adopted in the dossier.

The results of above tests are as follows:

96h LC50 - fish (Pimephales promelas) is 70.3 mg/l;

48h EC50 - Daphnia magna is 71.6 mg/l;

72h ErC50 - algae (Desmodesmus subspicatus) is 48 mg/l, and NOEC of which is 18 mg/l.

3h EC50 - microorganisms in sludge is above 200 mg/l, also the NOEC is above 200 mg/l.

Additionally, long term studies for aquatic toxicity have been performed following approval of testing proposals with daphnia and fish.

In a fish early life stage test according to OECD 210 (GLP-study) no mortality or effects on hatching were seen up to the highest concentration tested. Thus, the NOEC was set to ≥ 60 mg/L in this study.

Following approval of a testing proposal one valid experiment according to OECD 211 was performed using five concentrations (5.6, 11, 19, 34, and 60 mg/L test item) to investigate effects on reproduction to daphnia magna following exposure to sulfamic acid.

Significant decrease in the reproduction of the daphnia could not be observed but in the two highest treatments (34 and 60 mg/L respectively). Therefore, the NOEC was set to 19 mg/L and the LOEC to 34 mg/L in this study. The EC50 was found > 60 mg/L.