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EC number: 931-434-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment (test substance was applied for only 14 days but twice daily, test substance volume unclear).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
- Principles of method if other than guideline:
- Repeated application (twice daily) of the test substance to mice.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Esterification products of D-glucitol with C8 – C16 (even-numbered) and C18 unsaturated fatty acids
- EC Number:
- 931-434-7
- Cas Number:
- 1338-39-2
- Molecular formula:
- C18H34O6
- IUPAC Name:
- Esterification products of D-glucitol with C8 – C16 (even-numbered) and C18 unsaturated fatty acids
- Reference substance name:
- 931-434-7
- EC Number:
- 931-434-7
- IUPAC Name:
- 931-434-7
- Details on test material:
- - Name of test material (as cited in study report): Dehymuls SML, Sorbitanmonolaurat
- Physical state: clear yellow liquid
- Analytical purity: 100%
- Lot/batch No.: LOT 202
- Other information: soluble in mineral oil, dispersible in water
Note: Due to analytical test results the substance is defined as UVCB. For further details see IUCLID Chapter 1.2.
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- other: HRS hr/hr
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: adult, not further specified
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- water
- Details on exposure:
- TEST SITE
- Area of exposure: back skin, not further specified
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 drops
- Concentration (if solution): 10 and 50%
- Constant volume or concentration used: no - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 14 days
- Frequency of treatment:
- twice daily for 5 days per week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10 and 50%
Basis:
no data
- No. of animals per sex per dose:
- 5
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Dermal irritation:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 50 other: %
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: No effects were observed after a repeated application of the test substance as 50% solution (twice daily for 14 days) to the skin of mice.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
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