Registration Dossier
Registration Dossier
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EC number: 212-485-8 | CAS number: 822-06-0
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEC
- 1.15 mg/m³
- Study duration:
- chronic
- Species:
- rat
- Quality of whole database:
- The study is GLP compliant and is of high quality (Klimisch score=1)
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Carcinogenicity
Not classified under Annex I of Directive 67/548/EEC. According to Annex I of Regulation (EC) No 1272/2008 no classification is required for carcinogenicity.
Additional information
In a combined chronic toxicity and oncogenicity study in rats according to OECD TG 453 HDI revealed no carcinogenic potential after 2-year inhalation (whole-body) with vapour concentrations of 0.005, 0.025, 0.164 ppm (0.035, 0.175, 1.15 mg/m3). A Maximum Tolerated Dose (MTD) was established at the highest concentration tested (Shiotsuka, 1989).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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