Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 203-550-1 | CAS number: 108-10-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
MIBK possesses a 96-hour LC50 in freshwater fish > 179 mg/L, and has been shown to possess a 96-hour EC50 in Daphnia magna > 200 mg/L. The NOEC (21 d) of MIBK in the Daphnia sp. reproduction test was reported to be 78 mg/L (nominal) or 30-35 mg/L (measured). The growth inhibition test in freshwater Lemna gibba was > 146 mg/L. The toxicity to microorganisms is predicted to possess a 3 hour EC50 greater than 100 mg/L in activated sludge of a predominantly domestic sewage system, based on the read-across substance MIBC. Metabolic data demonstrate that methyl i-butyl carbinol is rapidly and extensively converted to the methyl i-butyl ketone via oxidation of the alcohol functional group by alcohol dehydrogenase in the liver. Methyl i-butyl ketone is subjected to further oxidative metabolism (hydroxylation) by the hepatic microsomal mixed function oxidase system to produce 4-hydroxymethyl-4-methyl-2-pentanone (i.e., diacetone alcohol), which is the major metabolite formed from both methyl i-butyl carbinol and methyl i-butyl ketone exposures. This is documented in the methyl i-butyl carbinol REACh dossier documentation (EC# 203-551-7). Thus, methyl i-butyl ketone may be used as an appropriate surrogate for methyl i-butyl carbinol and vice versa considering that the alcohol is rapidly metabolized to the ketone and that exposure to either substance ultimately results in the rapid formation of diacetone alcohol.The substance should therefore not be classified on the basis of absence of toxic effect whatever is the trophic level considered.
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