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Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1951
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The work of this group pre-dates range finding toxicity guidelines and provided much of the basis for their development. Their results are cited by many subsequent authoritative review bodies and are often found in SIDS and SIAR documents via secondary references. Therefore, these results are deemed reliable.

Data source

Reference
Reference Type:
publication
Title:
RANGE-FINDING TOXICITY DATA: LIST IV
Author:
Smyth HF, Carpenter CP & Weil CS
Year:
1951
Bibliographic source:
AMA Arch Ind Hyg Occup Med, 4, 119-122

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Remarks:
Insufficient reporting of methodology and results
GLP compliance:
no
Remarks:
study pre-dates GLP requirements
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-methylpentan-2-one
EC Number:
203-550-1
EC Name:
4-methylpentan-2-one
Cas Number:
108-10-1
Molecular formula:
C6H12O
IUPAC Name:
4-methylpentan-2-one
Details on test material:
-Name of test material (as cited in study report): 4-methyl-2-pentanone

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: no data
Details on inhalation exposure:
No data
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
2000 and 4000 ppm (8.2 and 16.4 mg/l)
No. of animals per sex per dose:
6 animals/dose level
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LC50
Effect level:
> 2 000 - < 4 000 ppm
Based on:
test mat.
Exp. duration:
4 h
Sex:
male
Dose descriptor:
LC50
Effect level:
11.6 mg/L air
Exp. duration:
4 h
Remarks on result:
other: Calculated with a standard probit model
Mortality:
At the 2000 ppm dose level, 0/6 animals died and at the 4000 ppm level all animals died.
Clinical signs:
other: No data
Body weight:
No data
Gross pathology:
No data

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Harmful if inhaled CLP (EC 1272/2008)
Executive summary:

An LC50 was not reported by the authors however, as none of the animals died at 2000 ppm and all of the animals died at 4000 ppm the LC50 is anticipated to be greater than 2000 ppm but less than 4000 ppm (8.2 and 16.4 mg/l).