Registration Dossier
Registration Dossier
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EC number: 201-550-6 | CAS number: 84-66-2
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Review paper published in peer reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 000
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- Diethyl phthalate
- EC Number:
- 201-550-6
- EC Name:
- Diethyl phthalate
- Cas Number:
- 84-66-2
- Molecular formula:
- C12H14O4
- IUPAC Name:
- .
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl (WI) BR
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- peanut oil
- Duration of treatment / exposure:
- once/day
- Frequency of treatment:
- daily
- Duration of test:
- 3d
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 50, 150 & 500 mg/kg/day
Basis:
nominal conc.
- No. of animals per sex per dose:
- 10
- Control animals:
- yes, concurrent vehicle
- other: single dose of 0.4 mg/kg B oestradiol as a positive control
Results and discussion
Any other information on results incl. tables
There were no treatment related effects on clinical observations or body weights. Uterus weight was also unaffected by treatment with DEP while the positive control produced a significant effect on uterine weight.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
