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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1987
Reference Type:
study report
Title:
Unnamed
Year:
1999
Reference Type:
secondary source
Title:
SIDS Category of Alkyl sulfates, Alkane sulfonates and Alpha-olefin sulfonates
Author:
OECD
Year:
2007
Bibliographic source:
UNEP Publications

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
The study was performed under occlusive conditions. No data on vehicle availabe.
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
90583-18-9 (purity 40.9-42%)
IUPAC Name:
90583-18-9 (purity 40.9-42%)
Details on test material:
- Name of test material (as cited in study report): trade name
- Physical state: No data
- Analytical purity: 40.9-42% a.i.
- Lot/batch No.: No data
- Storage condition of test material: No data

Test animals

Species:
rabbit
Strain:
other: Kleinrusse Chbb:HM

Test system

Type of coverage:
occlusive
Vehicle:
not specified
Controls:
not required
Amount / concentration applied:
Concentration: 25% a.i.
Amount applied: 0.5 mL
Duration of treatment / exposure:
4 hours
Observation period:
21 days
Number of animals:
5

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
other: mean of all 5 animals
Time point:
24/48/72 h
Score:
3.7
Max. score:
4
Reversibility:
fully reversible
Irritation parameter:
edema score
Basis:
other: mean of all 5 animals
Time point:
24/48/72 h
Score:
2.1
Max. score:
4
Reversibility:
fully reversible

Any other information on results incl. tables

time (hrs)                        time (days)
           1      24      48      72         7     10    14
mean E     1.8    3.6     3.8     3.6        2.8   1.8   0
mean O     0      1.8     2.4     2.2        1.8   1.4   0

E = erythema
O = oedema

Reversibility: yes

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU