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Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
toxicity to reproduction
Remarks:
other: Mammalian germ cell cytogenetic assay
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Significant methodological deficiences

Data source

Reference
Reference Type:
publication
Title:
Mutagenitatsprufung in Spermakopftest/Maus und mutagene Potenz van 2 Densinfektionsmitteln auf Basis von Peressigsaure bzw Phenolen
Author:
Koch S. et al
Year:
1989
Bibliographic source:
Zbl Hyg 188:391-403

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Mammalian germ cell cytogenetic assay
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
ICR
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Duration of treatment / exposure:
Exposure period: 5 days
Frequency of treatment:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
1.3 and 2.6 mg peracetic acid/kgbw/d
Basis:
other: injection intraperitoneal
Control animals:
yes

Results and discussion

Overall reproductive toxicity

Reproductive effects observed:
not specified

Any other information on results incl. tables

RESULTS
The results showed that a dose of 2.6 mg peracetic acid/kgbw doubled the incidence of sperm head abnormalities. When the dose was reduced to 1.3 mg/kgbw, no increase in anomalies was seen. Statistically significant results were not found at two consecutive dose levels. There is no sufficient evidence from this study to conclude if treatment caused abnormal sperm heads.

Applicant's summary and conclusion