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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: basic information given

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Epidemiological and Toxicological Aspects of Nitrates and Nitrites in the Environment.
Author:
Shuval, H.I. and Gruener, N.:
Year:
1972
Bibliographic source:
AJPH 62, 1045-1052
Reference Type:
study report
Title:
Unnamed
Year:
1977

Materials and methods

Objective of study:
toxicokinetics

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium nitrite
EC Number:
231-555-9
EC Name:
Sodium nitrite
Cas Number:
7632-00-0
Molecular formula:
HNO2.Na
IUPAC Name:
sodium nitrite

Test animals

Species:
rat
Details on test animals or test system and environmental conditions:
pregnant rats

Administration / exposure

Details on study design:
The study was conducted on pregnant white albino rats. The transfer of nitrites to the fetus in situ and the production of MetHb was tested.

Results and discussion

Toxicokinetic / pharmacokinetic studies

Toxicokinetic parameters
Toxicokinetic parameters:
other: The results of this study demostrated that nitrites were apparently not transfered in appreciable amounts to suckling rats.

Applicant's summary and conclusion

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