Registration Dossier
Registration Dossier
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EC number: 231-555-9 | CAS number: 7632-00-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic information given
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VII
- Author:
- Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U., Striegel, J.A., Nycum, J.S.
- Year:
- 1 969
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 30, 470-476
Materials and methods
- Principles of method if other than guideline:
- according to Thompson W.R., Bacteriol. Rev. 11:115 using the Tables of Weil C.S. Biometrics 8:249, 1952
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium nitrite
- EC Number:
- 231-555-9
- EC Name:
- Sodium nitrite
- Cas Number:
- 7632-00-0
- Molecular formula:
- HNO2.Na
- IUPAC Name:
- sodium nitrate
- Details on test material:
- sodium nitrite
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- four to five weeks of age and 90 to 120 grams in weight which have been reared in the colony and maintained from time of weaning on Rockland rat diet, complete.
Administration / exposure
- Route of administration:
- other: gastric intubation
- Details on oral exposure:
- Whenever possible, the chemical is administered undiluted. When a lesser concentration is necessary, solution in water or corn oil or suspension in semi-solid agar are the preferred expedients. Occasionally, a 1% solution of TERGITOL Penetrant 7 (essentially an aqueous solution of 25% sodium 3,9 diethyl-6-tridecanol sulfate) has been used as a dispersing agent.
- Doses:
- 180 mg/kg; intubated as 0.010 gm/ml concentration
- Control animals:
- not specified
- Details on study design:
- The dosages are arranged in a logarithmic series differing by a factor of two.
Occasionally, a 1% solution of TERGITOL Penetrant 7 (essentially an aqueous solution of 25% sodium 3,9 diethyl-6-tridecanol sulfate) has been used as a dispersing agent. Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the Tables of Weil. The figures in parentheses show limits of + 1.96 standard deviations while the absence of parentheses indicates that no range is calculable because no dosage resulted in fractional mortality.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 180 mg/kg bw
- Mortality:
- no data
- Clinical signs:
- other: no data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
