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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: basic information given

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VII
Author:
Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U., Striegel, J.A., Nycum, J.S.
Year:
1969
Bibliographic source:
Am. Ind. Hyg. Assoc. J. 30, 470-476

Materials and methods

Principles of method if other than guideline:
according to Thompson W.R., Bacteriol. Rev. 11:115 using the Tables of Weil C.S. Biometrics 8:249, 1952
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium nitrite
EC Number:
231-555-9
EC Name:
Sodium nitrite
Cas Number:
7632-00-0
Molecular formula:
HNO2.Na
IUPAC Name:
sodium nitrite
Details on test material:
sodium nitrite

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
four to five weeks of age and 90 to 120 grams in weight which have been reared in the colony and maintained from time of weaning on Rockland rat diet, complete.

Administration / exposure

Route of administration:
other: gastric intubation
Details on oral exposure:
Whenever possible, the chemical is administered undiluted. When a lesser concentration is necessary, solution in water or corn oil or suspension in semi-solid agar are the preferred expedients. Occasionally, a 1% solution of TERGITOL Penetrant 7 (essentially an aqueous solution of 25% sodium 3,9 diethyl-6-tridecanol sulfate) has been used as a dispersing agent.
Doses:
180 mg/kg; intubated as 0.010 gm/ml concentration
Control animals:
not specified
Details on study design:
The dosages are arranged in a logarithmic series differing by a factor of two.
Occasionally, a 1% solution of TERGITOL Penetrant 7 (essentially an aqueous solution of 25% sodium 3,9 diethyl-6-tridecanol sulfate) has been used as a dispersing agent. Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the Tables of Weil. The figures in parentheses show limits of + 1.96 standard deviations while the absence of parentheses indicates that no range is calculable because no dosage resulted in fractional mortality.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
180 mg/kg bw
Mortality:
no data
Clinical signs:
no data
Body weight:
no data

Applicant's summary and conclusion

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