Registration Dossier

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary source

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1985

Materials and methods

Principles of method if other than guideline:
Method: other
GLP compliance:
yes
Remarks:
according to SIDS

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium nitrite
EC Number:
231-555-9
EC Name:
Sodium nitrite
Cas Number:
7632-00-0
Molecular formula:
HNO2.Na
IUPAC Name:
sodium nitrate
Details on test material:
sodium nitrite

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
nose only
Vehicle:
other:
Duration of exposure:
4 h
Concentrations:
10 and 100 mg/m3
No. of animals per sex per dose:
10
Details on study design:
Aerosols dried rapidly so animals were exposed to dry particulate test material. Air humidity was approximately 60%. Mass mean aerodynamic diameter was 1.7 and 2.0 ìm for the low and high groups, respectively. Controls killed after exposure and blood taken for measurement of methaemoglobin, the remaining animals were maintained for 14 days, and then subject to a full post-mortem examination.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
0.095 mg/L air
Exp. duration:
4 h
Clinical signs:
other: During exposure signs typically seen in restrained animals were somewhat more severe in treated animals. Methaemoglobin was significantly increased above concurrent control values only in females exposed to 10 mg/m3. However, the increase was judged to be

Applicant's summary and conclusion

Conclusions:
Current controls of exposure of workers to sodium nitrite
(i.e. at 10 mg/m3) was more than adequately protective for
acute hazards.