Registration Dossier

Administrative data

Endpoint:
sediment toxicity: long-term
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2009
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
Given their physico-chemical properties, including being highly insoluble in water, their use pattern, and the fact that LCCPs did not demonstrate aquatic toxicity up (and in many cases exceeding) their water solubility limites, LCCPs are not expected to present a significant risk to sediment organisms.The equilibrium partitioning approach has been used to estimate effect levels.

Data source

Reference
Reference Type:
publication
Title:
Environmental Risk Evaluation Report for LCCPs
Author:
Environment Agency
Year:
2009
Bibliographic source:
Environment Agency
Report date:
2009

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
The equilibrium partitioning model was used to generate these results.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Paraffin waxes and Hydrocarbon waxes, chloro
EC Number:
264-150-0
EC Name:
Paraffin waxes and Hydrocarbon waxes, chloro
Cas Number:
63449-39-8
Molecular formula:
C18H33Cl5 C18H30Cl8 C20H36Cl6 C20H33Cl9 C25H45Cl7 C25H42Cl10 C25H29C23 C30H53Cl9 C30H49Cl13 C30H35Cl27
IUPAC Name:
Paraffin waxes and Hydrocarbon waxes (C18 and longer), chloro
Test material form:
other: liquid or solid
Specific details on test material used for the study:
Modelled data considering C18-20 liquid LCCP, C20+ liquid LCCP and C20+ solid LCCP

Sampling and analysis

Analytical monitoring:
not required
Remarks:
Modelled data

Test substrate

Vehicle:
no

Test organisms

Test organisms (species):
other: Modelled data

Study design

Study type:
other: Modelled data
Test type:
not specified
Water media type:
other: Modelled data
Type of sediment:
not specified
Remarks:
Modelled data
Limit test:
no

Results and discussion

Effect concentrationsopen allclose all
Dose descriptor:
other: PNEC
Effect conc.:
5 710 other: mg/kg ww
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
other: Modelled data using equilibrium partitioning method
Remarks on result:
not measured/tested
Dose descriptor:
other: PNEC
Effect conc.:
33 100 other: mg/kg ww
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
other: Modelled data using equilibrium partitioning method
Remarks on result:
not measured/tested
Dose descriptor:
other: PNEC
Effect conc.:
120 000 other: mg/kg ww
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
other: Modelled data using equilibrium partitioning method
Remarks on result:
not measured/tested
Details on results:
PNECsed = (Ksusp-water × PNECwater × 1000)/RHOsusp

where Ksusp-water = suspended matter-water partition coefficient
= 2.27×106 m3/m3 for C18–20 liquid chlorinated paraffin
= 6.93×106 m3/m3 for C>20 liquid chlorinated paraffin
= >2.5×108 m3/m3 for C>20 solid chlorinated paraffin

RHOsusp = bulk density of suspended matter = 1,150 kg/m3

Using this equation, the following PNECsed can be derived:
C18–20 liquid chlorinated paraffin PNECsed = 5,710 mg/kg wet wt.
C>20 liquid chlorinated paraffin PNECsed(screening) = 33,100 mg/kg wet wt.
C>20 solid chlorinated paraffin PNECsed(screening) = >1,200,000 mg/kg wet wt.

Applicant's summary and conclusion

Conclusions:
Based on the equilibrium partitioning method, the UK EA (LCCP Environmental Risk Assessment, January 2009) derived the following sediment PNECs for LCCP (based on product type):
C18–20 liquid chlorinated paraffin PNECsed = 5,710 mg/kg wet wt.
C>20 liquid chlorinated paraffin PNECsed(screening) = 33,100 mg/kg wet wt.
C>20 solid chlorinated paraffin PNECsed(screening) = >1,200,000 mg/kg wet wt.
Executive summary:

Based on the equilibrium partitioning method, the UK EA (LCCP Environmental Risk Assessment, January 2009) derived the following sediment PNECs for LCCP (based on product type):

C18–20 liquid chlorinated paraffin PNECsed = 5,710 mg/kg wet wt.

C>20 liquid chlorinated paraffin PNECsed(screening) = 33,100 mg/kg wet wt.

C>20 solid chlorinated paraffin PNECsed(screening) = >1,200,000 mg/kg wet wt.