Registration Dossier

Toxicological information

Acute Toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1964
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1964
Report date:
1964

Materials and methods

GLP compliance:
no
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Paraffin waxes and Hydrocarbon waxes, chloro
EC Number:
264-150-0
EC Name:
Paraffin waxes and Hydrocarbon waxes, chloro
Cas Number:
63449-39-8
Molecular formula:
C18H33Cl5 C18H30Cl8 C20H36Cl6 C20H33Cl9 C25H45Cl7 C25H42Cl10 C25H29C23 C30H53Cl9 C30H49Cl13 C30H35Cl27
IUPAC Name:
Paraffin waxes and Hydrocarbon waxes (C18 and longer), chloro
Details on test material:
C22-30; 70% Cl (solid); stabilized with 1.0% epoxidised vegetable oil, 0.05% hydrated oxalic acid and 0.05% ethylene glycol. Cereclor 70 (stabilized).

Test animals

Species:
rat
Strain:
not specified
Sex:
female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: 50% suspension in dispersing agent
Details on exposure:
Three female rats were given 5.0 g/kg bw of the test material i.p. and observed for one week.
Doses:
5.0 g/kg/bw
No. of animals per sex per dose:
3
Control animals:
not specified
Details on study design:
No data
Statistics:
No data

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw

Any other information on results incl. tables

All animals showed piloerection, slight urinary incontinence, muscular weakness and slight forelimb tremor. The effects abated but, after one week, they all remained weak and were unsteady. No pathological lesions were noted but the substance seemed to precipitate on the viscera and mesentery. A moderate ascites was present.

Applicant's summary and conclusion

Conclusions:
All animals showed piloerection, slight urinary incontinence, muscular weakness and slight forelimb tremor. The effects abated but, after one week, they all remained weak and were unsteady. No pathological lesions were noted but the substance seemed to precipitate on the viscera and mesentery. A moderate ascites was present.