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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1978
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
Principles of method if other than guideline:
Repeated daily occlusive administration.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Paraffin waxes and Hydrocarbon waxes, chloro
EC Number:
264-150-0
EC Name:
Paraffin waxes and Hydrocarbon waxes, chloro
Cas Number:
63449-39-8
Molecular formula:
C18H33Cl5 C18H30Cl8 C20H36Cl6 C20H33Cl9 C25H45Cl7 C25H42Cl10 C25H29C23 C30H53Cl9 C30H49Cl13 C30H35Cl27
IUPAC Name:
Paraffin waxes and Hydrocarbon waxes (C18 and longer), chloro
Details on test material:
C22-26; 42% Cl (liquid) (stabilised). Meflex DC016. Stabiliser: 0.2% epoxy soya bean oil, 0.3% Lubrizol LZ55A. 0.3% polyethylene glycol and 0.2% Nonox WSL.

Test animals

Species:
rat
Strain:
not specified

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
6 repeated occlusive, topical applications (0.1ml)
Duration of treatment / exposure:
12 days with 6 alternate decontaminations.
Observation period:
No data
Number of animals:
3

Results and discussion

In vivo

Results
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 4 application
Score:
< 1
Reversibility:
fully reversible
Remarks on result:
other: slight erythema and desquamation observed in 1 of 3 rats after 4th application.

Any other information on results incl. tables

Slight erythema and desquamation was observed in 1 out of 3 rats after the 4th application. The effect was not present by the final day of the test. It was concluded that the substance was practically non-irritant

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Slight erythema and desquamation was observed in 1 out of 3 rats after the 4th application. The effect was not present by the final day of the test. It was concluded that the substance is not classifiable as an irritant.
Executive summary:

Slight erythema and desquamation was observed in 1 out of 3 rats after the 4th application. The effect was not present by the final day of the test. It was concluded that the substance is not classifiable as an irritant.