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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993

Materials and methods

Principles of method if other than guideline:
other: respiratory irritation
GLP compliance:
yes
Test type:
other: respiratory sensitization

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Specific details on test material used for the study:
Supplier: Methacrylate Producers assiciation, Washington DC

Test animals

Species:
mouse
Strain:
Swiss Webster
Sex:
male

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
other: no data
Details on inhalation exposure:
Due to low vapor pressure, Lauryl methacrylate was generated as an aerosol.
Duration of exposure:
30 min
Concentrations:
460, 1500, 2100, 2900, or 3800 mg/m³
No. of animals per sex per dose:
4 per dose group
Details on study design:
Groups of four male Swiss Webster mice were exposed for a single, 30-minute period to a concentration of airborne test substance in air to  assess sensory irritation potential. Mice were first weighed then placed  into body plethysmographs 
prior to exposure and acclimated to the  exposure chamber for approximately ten minutes. During this preexposure,  
respiratory rates were monitored and recorded to establish a baseline  respiration rate. Exposure to the test substance 
was conducted during the  next 30 minutes followed by a post exposure monitoring period of at least  10 minutes. Mice 
were then removed from the chamber, weighed, and  observed for clinical signs of toxicity prior to sacrifice. Respiratory  
function parameters were monitored during all preexposure, exposure, and  postexposure periods.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
other: RD50
Effect level:
3 900 mg/m³ air (nominal)
Based on:
test mat.
Exp. duration:
30 min

Any other information on results incl. tables

RD50: calculated concentration that will produce a 50 % depression in respiratory rate
Exposures to 460, 1500, 2100, 2900, or 3800 mg/m3 of Lauryl methacrylate caused both respiratory rate decreases and
persistent breathing patterns of sensory irritation at the higher concentrations. The decrease in respiratory rate and
the severity of irritation was dose-dependent.
The high RD50 level indicate a low potential for causing upper respiratory tract irritation.

Applicant's summary and conclusion

Conclusions:
The high RD50: 3.9 mg/L level for Dodecyl methacrylate indicate a low potential for causing upper respiratory tract irritation.