Registration Dossier
Registration Dossier
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EC number: 202-496-6 | CAS number: 96-29-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Butanone oxime
- EC Number:
- 202-496-6
- EC Name:
- Butanone oxime
- Cas Number:
- 96-29-7
- Molecular formula:
- C4H9NO
- IUPAC Name:
- (NE)-N-butan-2-ylidenehydroxylamine
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 95 to 125 g.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- from 1500 to 4999 mg/kg bw
- No. of animals per sex per dose:
- At least 9 males/dose
- Control animals:
- yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- ca. 1 500 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 326 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred at 1500 mg/kg; 22.2% deaths occurred at 1,908 mg/kg, 50% deaths occurred at 2,427 mg/kg, and 100% deaths occurred at 3,089 mg/kg or higher. Deaths generally occurred within 48 hours of dosing.
- Clinical signs:
- other: Signs of toxicity included general depression, tremors followed by loss of righting reflex.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008
- Conclusions:
- The estimated LD50 for methyl ethyl ketoxime in male Sprague-Dawley rats is 2326 mg/kg body weight.
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