2-ethoxyethanol

Biological effects monitoring

Administrative data

Endpoint:

biological effects monitoring

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable procedure and publication

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Cytotoxicity of 109 Chemicals to Goldfish GFS Cells and Relationships with 1-Octanol/Water Partition Coefficients

Author:

Saito, H. et al.

Year:

1993

Bibliographic source:

Chemosphere 26(5), 1015-1028

Reference 2

Reference Type:

publication

Title:

Quantitative Structure-Activity Relationships in Fish Toxicity Studies

Author:

Koenemann, H.

Year:

1981

Bibliographic source:

Toxicology, 19, 209-221

Materials and methods

Principles of method if other than guideline:

Neutral red (NR) assay

GLP compliance:

not specified

Type of study / information:

Midpoint cytotoxicity of 2-ethoxyethanol to goldfish scale GFS cells compared with the fish acute toxicities and partition coefficient (log Pow).

Test material

Test material information

Constituent 1

Reference substance name:

2-ethoxyethanol

EC Number:

203-804-1

EC Name:

2-ethoxyethanol

Cas Number:

110-80-5

Molecular formula:

C4H10O2

IUPAC Name:

2-ethoxyethan-1-ol

Details on test material:

Name of the test substance as stated in the publication: 2-ethoxyethanol
Purchased from: Tokyo Kasei Kogyo Co., Tokyo, Japan;
Purity: " reagent-grade"

Results and discussion

Any other information on results incl. tables

Data of log Pow, NR50 for GFS cells and LC50 for guppy: (log Pow and LC50 values from Koenemann, H. (1981))

	Log Pow	Log 1/NR50 (mmol/L)	Log 1/LC50 (mmol/L), guppy
2 -ethoxyethanol	-0.21	-2.54	-2.26

Applicant's summary and conclusion

Conclusions:

The 24-hr NR50 values (in vitro) for the cytotoxicity of the test compound 2-ethoxyethanol to GFS cells, together with their log Pow and LC50 data (in vivo) for guppy gave good correlations.