Registration Dossier
Registration Dossier
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EC number: 617-969-6 | CAS number: 87135-01-1
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
log Kow [1,6-Bis(trimethoxysilyl)hexane]: 1.7 at 20°C (QSAR)
log Kow [1,6-Bis(trihydroxysilyl)hexane]: -3.5 at 20°C (QSAR)
log Kow [methanol]: -0.82 to -0.64
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.7
- at the temperature of:
- 20 °C
Additional information
The requirement to conduct an n-octanol/water partition coefficient study was waived because the substance hydrolyses rapidly in contact with water to form 1,6-bis(trihydroxysilyl)hexane and methanol.
However, the log Kow of the parent alkoxysilane was predicted to be 1.7 at 20°C using a validated QSAR estimation method. This result is considered to be reliable and is used for assessment purposes. A measured log Kow value of 3.7 at 40°C and pH 7.5 was determined for the substance in a disregarded study because the selected mobile phase constituents were unsuitable for this type of substance. Also, an important corrective adjustment that would be necessary to validly interpret the result was lacking.
The log Kow of the silanol hydrolysis product was determined to be -3.5 at 20°C using a validated QSAR estimation method.
Methanol has a reported log Kow of -0.82 to -0.64 (OECD 2004).
OECD (2004): SIDS Initial Assessment Report for SIAM 19, Berlin, Germany, 18-20 October 2004, Methanol, CAS 67-56-1.
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