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EC number: 201-083-8 | CAS number: 78-10-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001/01/29 - 2001/04/02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Tetraethyl orthosilicate
- EC Number:
- 201-083-8
- EC Name:
- Tetraethyl orthosilicate
- Cas Number:
- 78-10-4
- Molecular formula:
- C8H20O4Si
- IUPAC Name:
- tetraethyl orthosilicate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar HsdCpb:WU
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Winkelmann GmbH, Borchen, Districts of Paderborn
- Age at study initiation: ca. 8 weeks
- Weight at study initiation: 185-187g males, 159-175g females
- Housing: During the acclimatization period the animals were kept conventionally in polycarbonate cages type III (animals <180 g bw - five animals, of >180 g - max three animals per cage). The cages were changed at least three times a week. Feed racks and water bottles were not changed. During the test period the animals were kept conventionally in polycarbonate cages type III (three animals per cage). The cages were changed at least once a week. Feed racks and water bottles were not changed. The bedding consisted of low dust wood granules type BK 8/15.
- Diet: "NAFAG No.9439 Long Life W 10", ad libitum (approx. 2 hours after administration)
- Fasting: 17 hours +/- 2 before administration
- Water: tap water, ad libitum
- Acclimation period: minimum of 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): ca. 22 +/- 2
- Humidity (%): 55 +/- 5
- Air changes (per hr): ca. 15-20
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Details on oral exposure:
- DOSE VOLUME ADMINISTERED: 5 mL/kg bw
DOSAGE PREPARATION (if unusual): The test substance was formulated in polyethylene glycol 400 before administration. The applied formulations were well mixed by pumping the syringe several times. - Doses:
- 2000 mg/kg bw, single dose
- No. of animals per sex per dose:
- 3M, 3F
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: appearance and behaviour were recorded several times on the day of treatment, and at least once a day thereafter. Where sign occurred, the type, period and intensity were determined individually. The body weights of the rats were recorded on day 1 before administration and then weekly. Additionally, all animals that died or were sacrificed were weighed.
- Necropsy of survivors performed: yes
- Examinations performed: clinical signs, body weight, gross pathology, other: During clinical observation all abnormal findings were registered and particular attention was paid to the following organ systems, localizations and physiological functions: appearance - fur, skin colour, edemas, eyes, lacrimation, nasal discharge, salivation; behaviour - grooming, vocalization, excitement, aggression, digging and preening movements, cannibalism; nervous system - reactivity, motility, reflexes, gait, paralysis, spasms, tremors; where accessible - respiration frequency and heart rate, pallor; posture, and gastrointestinal functions - appearance of feces, etc. - Statistics:
- No statistical analysis was carried out.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no deaths.
- Clinical signs:
- other: There were no clinical signs.
- Gross pathology:
- No gross pathologic changes were observed in animals sacrificed at the end of the study period.
- Other findings:
- No other findings reported.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the key acute oral study for tetraethyl orthosilicate (reliability score 1), the LD50 value of >2000 mg/kg bw in the rat was determined in a reliable study conducted according to OECD Test Guideline 423 and in compliance with GLP. There were no clinical signs or effects on body weight or gross pathology observed.
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