2-(2-(2-methoxyethoxy)ethoxy)ethanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

04 Feb 1974 - 12 Feb 1974

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

The test was performed according to the principles described in OECD Guideline 403.
The test demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at the temperature chosen. The documentation of clinical signs was performed over a period of 7 days. In order to verify the results, the test was repeated once.

GLP compliance:

no

Test type:

other: Inhalation hazard test

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2-(2-(2-methoxyethoxy)ethoxy)ethanol

EC Number:

203-962-1

EC Name:

2-(2-(2-methoxyethoxy)ethoxy)ethanol

Cas Number:

112-35-6

Molecular formula:

C7H16O4

IUPAC Name:

2-[2-(2-methoxyethoxy)ethoxy]ethan-1-ol

Details on test material:

- Name of test material (as cited in study report): Methylentriglykol. Test substance No. 88/289
- Physical state: liquid
- Analytical purity: ca. 95%

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: male: 172g (mean), female: 161g (mean)

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Temperature in air chamber and for vapour generation: 20°C
- 3 rats per sex were exposed sequentially to the vapour.
- vapour generated by bubbling 200l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

0.15 mg/l

No. of animals per sex per dose:

6

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

> 10 ppm

Exp. duration:

8 h

Remarks on result:

other: figure nominally represents the saturated vapour concentration

Mortality:

No mortality was observed at saturated vapour concentration.

Clinical signs:

other: No clinical signs were observed.

Body weight:

male: 200g (mean)
female: 180g (mean)

Gross pathology:

No abnomalities were found at necropsy.

Any other information on results incl. tables

No clinical signs of toxicity or mortality were observed after an 8h inhalation of an atmosphere saturated with vapours of the volatile components of the test substance.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Executive summary:

In a vapour inhalation acute toxicity test carried out following the principles of the OECD guideline, male and female rats were exposed to a saturated vapour concentration of the test substance 2 -(2 -(2 -methoxyethoxy)ethoxy)ethanol for a period of 8 hours. No clinical signs of toxicity were reported. It can be concluded that the test substance does not present an acute inhalation hazard.