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EC number: 203-962-1 | CAS number: 112-35-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
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- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically reliable study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-(2-(2-methoxyethoxy)ethoxy)ethanol
- EC Number:
- 203-962-1
- EC Name:
- 2-(2-(2-methoxyethoxy)ethoxy)ethanol
- Cas Number:
- 112-35-6
- Molecular formula:
- C7H16O4
- IUPAC Name:
- 2-[2-(2-methoxyethoxy)ethoxy]ethan-1-ol
- Reference substance name:
- Triethylene glycol monomethyl ether
- IUPAC Name:
- Triethylene glycol monomethyl ether
- Details on test material:
- >98% triethylene glycol monomethyl ether
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 3 - 5 months
- Weight at study initiation: 2.8-3.l kg
- Housing: in a fully air-conditioned rooms in Einzelkafigen (Battery cages)
- Diet: Altromin 2123 Haltungsdiit - rabbits Altromin GmbH, Lage / Lippe, ad libitum and hay (about two cups of coffee 15g)
- Water: deionized, chlorinated water from automatic watering entities, ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature: 20±3 °C
- Humidity: 50 ± 20 %
- Photoperiod: 12 hours a day
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The untreated eye was used in each case as a control.
- Amount / concentration applied:
- 0.1 ml of triethylene was applied once into the conjunctival sac of the left eye.
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- No data
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.56
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- probability of weak irritation
- Remarks:
- For individual animal data see table in other information.
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
INDIVIDUAL FINDINGS:
Time post-application | 1h | 24h | 48h | 72h |
Animal number | 1 2 3 | 1 2 3 | 1 2 3 | 1 2 3 |
conjunctival swelling | 1 1 1 | 0 0 0 | 0 0 0 | 0 0 0 |
conjunctival redness | 1 2 1 | 1 1 2 | 0 0 1 | 0 0 0 |
Iris | 0 0 0 | 0 0 0 | 0 0 0 | 0 0 0 |
Corneal opacity | 0 0 0 | 0 0 0 | 0 0 0 | 0 0 0 |
Fluorescein-Test | 0 0 0 | 0 0 0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
In a guideline eye irritation study using the substance 2 -(2 -(2 -methoxyethoxy)ethoxy)ethanol, no corneal, iris or chemosis response was seen. Slight conjunctival redness was seen with an average score of 0.55 across the three observation timepoints of 24, 48, and 72 hours, but these effects fully resolved across all three animals by the time of the 72 hour observation. On this basis, the substance is regarded as not irritating for classification purposes.
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