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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: documentation sufficient for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Studies in detoxication. I. the influence of (a) dose and (b) o-m- and p-stubstitution on the suphate detoxication of phenol in rabbits
Author:
Williams BT
Year:
1938
Bibliographic source:
Biochem. J. 32, 878-887
Reference Type:
review article or handbook
Title:
EHC (Environmental Health Criteria) No. 168: Cresols
Author:
WHO
Year:
1995
Bibliographic source:
IPCS (International Programme on Chemical Safety) WHO, Geneva

Materials and methods

Objective of study:
metabolism
Principles of method if other than guideline:
Oral application by gavage to rabbits and urine was collected over 6 days and analysed vor total and inorganic sulphate by gravimetirc method of Folin et al (1932).
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
o-cresol
EC Number:
202-423-8
EC Name:
o-cresol
Cas Number:
95-48-7
Molecular formula:
C7H8O
IUPAC Name:
o-cresol
Details on test material:
Test substance: o-cresol, no data on purity

Test animals

Species:
rabbit
Strain:
not specified
Sex:
female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: approximately 2 kg
- Housing: singly
- Individual metabolism cages: yes
- Diet "mixed diet": 100 g cabbage , 50 g bran:
- Water ad libitum
- Acclimation period: no data


ENVIRONMENTAL CONDITIONS
- Temperature (°F):50-60

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on exposure:
no details given
Duration and frequency of treatment / exposure:
6 day(s)
Doses / concentrations
Remarks:
Doses / Concentrations:
Females: 290 mg/kg bw/day as aequous solution
No. of animals per sex per dose / concentration:
no data
Control animals:
not specified
Positive control reference chemical:
no data
Details on study design:
Oral application by gavage to rabbits and urine was collected over 6 days and analysed for total and inorganic sulphate by gravimetirc method of Folin et al (1932) every second day.
Details on dosing and sampling:
The urine was collected in a beaker placed at the orifice of the funnels which were changed every second day for cleaning.
Statistics:
no data

Results and discussion

Preliminary studies:
no data

Toxicokinetic / pharmacokinetic studies

Details on absorption:
no data
Details on distribution in tissues:
no data
Details on excretion:
A mean of 22 % of the applied dose was as conjugate with sulphate.

Metabolite characterisation studies

Metabolites identified:
no
Details on metabolites:
A mean of 22 % of the applied dose was as conjugate with sulphate (no further information).

Any other information on results incl. tables

22 % of the administered dose is excreted conjugated with sulphate.

Applicant's summary and conclusion

Executive summary:

Approximately 22 % of the administered o-cresol conjugated with sulfate was detected in the urinary excretion rate after oral application of 290 mg/kg bw o-cresol by gavage to female rabbits.