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EC number: 208-169-4 | CAS number: 513-79-1
Table 1: Pharmacokinetic parameter
Pharmacokinetic parameters of cobalt dichloride hexahydrate, tricobalt tetraoxide or cobalt stearat in rats (Non-compartmental analysis)
Dose level [mg/kg]
Cobalt dichloride hexa-hydrate
#: No dose correction to the Cobalt content was performed.
- : not applicable
- clinical signs: no signs of local intolerance reactions were noted at the injection sites of the rats treated once intravenously with 0.1 mg cobalt dichloride hexahydrate/kg bw. None of the rats treated once intravenously with 0.1 mg cobalt dichloride hexahydrate/kg bw showed any changes in behaviour or external appearance.
None of the rats treated once orally with 10 mg cobalt dichloride hexahydrate/kg bw, 300 mg tricobalt tetraoxide/kg bw or 5 mg cobalt stearate/kg bw showed any changes in behaviour or external appearance.
The faeces of the animals were normally formed.
None of the rats died prematurely.
- body weight: individual body weights ranged from 265.0 to 315.2 g for the male animals and from 149.5 to 183.2 g for the female animals on test day 1 and were within the expected range.
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