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EC number: 208-169-4 | CAS number: 513-79-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- - The purity and stability of the test material were not stated. Minor deviations with no effect on the study results: -According to the guideline, the volume administered to the animals should not exceed 1ml/100 g bw. The information on the volume administered was missing in the study report. -According to the guideline, the diet and environmental conditions shoud be stated in the test report. This information was missing in this report.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
- Reference Type:
- publication
- Title:
- Acute oral LD50 study in rats w Co(II) carbonate hydrate
- Author:
- Reagan
- Year:
- 1 992
- Bibliographic source:
- In: Richard Parent, (Ed.) Acute Toxicity Data. American College of Toxicology. Mary Ann Liebert Inc., (Pub.) Vol. 11, No. 6, p. 687.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- , see "rational for reliability"
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Cobalt carbonate
- EC Number:
- 208-169-4
- EC Name:
- Cobalt carbonate
- Cas Number:
- 513-79-1
- Molecular formula:
- CH2O3.Co
- IUPAC Name:
- λ²-cobalt(2+) carbonate
- Details on test material:
- - Name of test material (as cited in study report): Cobalt (II) carbonate hydrate
- Molecular formula: 16CoCO3 * Co(OH)2* 8H2O
- Lot No.: 030383
No further information on the test material was stated.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories, Inc., Wilmington, MA
- Weight at study initiation: Males 215- 253 g; females 182 - 219 g
- Fasting period before study: Food was withheld the night prior to dosing.
- Housing: Rats were individually housed in wire mesh bottom cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
Rats were held in environmentally controlled rooms.
No further information on the test animals was stated.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration prepared: 50 % suspension
PREPARATION PROCEDURE: Weighed 25 gm test article , Q.S. to 50 ml with diluent. The test article was administered at a constant concentration.
No further information on the oral exposure was stated.
- Doses:
- 300 mg/kg, 480 mg/kg, 770 mg/kg, 1240 mg/kg, 2000 mg/kg
- No. of animals per sex per dose:
- 5 males / 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing:Animals were observed frequently on the day of dosing and twice daily thereafter. Body weights were recorded initially (prior to dosing), on days 8 and 15 or at death.
- Necropsy of survivors performed: Yes
All animals that died during the study and those sacrificed at termination were subjected to a gross necropsy and abnormalities were noted.
No further information on the study design was stated. - Statistics:
- The LD50 value was determined according to Finney, D.J., 1971. Probit Analysis.Third Edition. Cambridge University Press. pp. 383.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 664 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 463 - <= 983
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 732 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 585 - <= 923
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 697 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 575 - <= 854
- Mortality:
- The following number of rats died at the different dose levels:
300 mg/kg: no rats died
480 mg/kg: 1 of 5 males (dead on day 7)
770 mg/kg: 3 of 5 males (dead on days 4,5,6); 3 of 5 females (dead on days 4,5,6)
1240 mg/kg: 5 of 5 males (dead on days 2,4,5,6); 5 of 5 females (dead on days 2,3, 4,5)
2000 mg/kg: 5 of 5 males (dead on days 3,4,6); 5 of 5 females (dead on day 3) - Clinical signs:
- other: The follwoing clinical sigsn were seen at the different dose levels: 300 mg/kg: Diarrhea ( 1 of 5 males) 480 mg/kg: Decreased activity ( 1 of 5 males); Diarrhea ( 2 of 5 males) 770 mg/kg: Decreased activity (4 of 5 males; 5 of 5 females); Ataxia (3 of 5 m
- Gross pathology:
- At the dose level 300 mg/kg, 480 mg/kg, 770 mg/kg and 2000 mg/kg no noteworthy necropsy findings were made.
At the dose level 1240 mg/kg the instestines were found to be red in 1 male rat. No noteworthy necropsy findings were made in the remaining rats at this dose level.
Any other information on results incl. tables
In the original paper the LD50 value was determined according to Miller and Tainter (Proc. Soc. Biol.Med. 57, 261 (1994)). The results were later new calculated according to Finney, D.J., 1971. Probit Analysis. Third Edition, Cambridge University Press. pp. 383. The LD50 values stated under "Effect levels" are the values obtained according to Finney (1971).
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The following LD50 values were found:
LD50 (male rats): 664 mg/kg (Confidence interval: 463 - 983 mg/kg)
LD50 (female rats): 732 mg/kg (Confidence interval: 585 - 923 mg/kg)
LD50 (male and female rats): 697 mg/kg (Confidence interval: 575 - 854 mg/kg)
According to the EC Regulation No. 1272/2008 and subsequent regulations, the test item is Category 4.
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