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EC number: 270-112-4 | CAS number: 68411-27-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 October 1978 to 31 October 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Benzoic acid, C12-15-alkyl esters
- EC Number:
- 270-112-4
- EC Name:
- Benzoic acid, C12-15-alkyl esters
- Cas Number:
- 68411-27-8
- Molecular formula:
- C19-22 H30-36 O2
- IUPAC Name:
- Benzoic acid, C12-15-alkyl esters
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Summit View Farm, Belvidere, New Jersey, USA
- Diet: Wayne animal feed, ad libitum
- Water: ad libitum
- Acclimation period: conditioned prior to use
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: left eye, remaining untreated, of each rabbit served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.1 ml, singe administration
- Concentration (if solution): undiluted, test material as received - Duration of treatment / exposure:
- 24 h ( no wash)
- Observation period (in vivo):
- 1, 2, and 3 days after treatment, and up to 7 days when necessary
- Number of animals or in vitro replicates:
- 6 (mixed sex), 1.8 - 2.4 kg
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): The trated eyes remained unwashed for 24 hours
SCORING SYSTEM: Draize standard scoring system:
Cornea Opacity (A) Grading 0-4
Area of Cornea Involved (B) Grading 0-4
Score equals A x B x 5 Total maximum = 80
Iris Values (A) Grading 0-2
Score equals A x 5 Total maximum = 10
Conjunctivae Redness (A) Grading 0-3
Chemosis (B) Grading 0-4
Discharge (C) Grading 0-3
Score equals (A + B + C) x 2 Total maximum = 20
Note: The maximum total score is the sum of all scores obtained for the cornea, iris and conjunctivae.
TOOL USED TO ASSESS SCORE: hand-held lenses
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- animal: 1 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: 1 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- animal: 1 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 1 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- chemosis score
- Basis:
- animal: 1 to 6
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritant / corrosive response data:
- Result: Draize Score
______________Day_________________
Group 1 2 3 4---------7
_______________________________________________
No Wash 0.0 0.0 0.0 --- ---
The test substance is not an ocular irritant to rabbits under the conditions of the test.
Any other information on results incl. tables
Rabbit Number |
Day |
Cornea: A x B x 5 + |
Iris: A x 5 + |
Conjunctivae: (A+B+C) x 2= |
Total Scores* |
1, 2, 3, 4, 5, 6 |
1 |
0 0 |
0 |
0 0 0 |
0 |
1, 2, 3, 4, 5, 6 |
2 |
0 0 |
0 |
0 0 0 |
0 |
1, 2, 3, 4, 5, 6 |
3 |
0 0 |
0 |
0 0 0 |
0 |
1, 2, 3, 4, 5, 6 |
4 |
- - |
- |
- - - |
- |
1, 2, 3, 4, 5, 6 |
7 |
- - |
- |
- - - |
- |
Average |
1 |
|
|
|
0.0 |
|
2 |
|
|
|
0.0 |
|
3 |
|
|
|
0.0 |
|
4 |
|
|
|
- |
|
7 |
|
|
|
- |
* Total score possible/animal/observation interval = 110
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material is not an ocular irritant to rabbits under the conditions of the test.
- Executive summary:
The test substance was tested in an eye irritation study. Six New Zealand rabbits, mixed sex, 1.8 - 2.4 kg, received 0.1 ml test substance (material used as received) in a single administration instilled in the right eye; the left eye, remaining untreated, served as control. The treated eyes of all rabbits remained unwashed for 24 hours. Observations of injuries on the cornea, iris and the bulbar and palpebral conjunctivae were made 1, 2, and 3 days after treatment; further readings were not necessary. Numerical scores were assigned according to the Draize standard scoring system.
Result: Draize Score
_________Day____________
Group 1 2 3 4-------7
No Wash 0.0 0.0 0.0 -- --
The test substance is not an ocular irritant to rabbits under the conditions of the performed test.
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