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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
publication
Title:
QSARS for the eye irritation potential of neutral organic chemicals.
Author:
Barratt, MD
Year:
1997
Bibliographic source:
Toxic in Vitro 11, 1-8.

Materials and methods

Type of study / information:
Type: other: QSAR (eye irritation)

Test material

Constituent 1
Chemical structure
Reference substance name:
Formamide
EC Number:
200-842-0
EC Name:
Formamide
Cas Number:
75-12-7
Molecular formula:
CH3NO
IUPAC Name:
formamide
Details on test material:
formamide

Results and discussion

Any other information on results incl. tables

RS-Freetext:
A Quantitative Structure-Activity Relationship (QSAR) was
derived previously relating European Community (EC) eye
irritation classification data of a set of neutral organic
chemicals, to log (octanol/water partition coefficient), to
minor principal inertial axes (Ry and Rx) and to dipole
moment. Eye irritation classification predicted by this QSAR
model was compared with in vivo data.
Formamide was classified as non-irritant by both QSAR and in
vivo data.

Applicant's summary and conclusion