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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1985
Report date:
1985

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD Guideline 411
GLP compliance:
yes
Test type:
other: 90-day repeated dose study
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Formamide
EC Number:
200-842-0
EC Name:
Formamide
Cas Number:
75-12-7
Molecular formula:
CH3NO
IUPAC Name:
formamide
Details on test material:
Formamide, purity >99%.

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Vehicle:
other: undiluted
Doses:
0, 300, 1000, 3000 mg/kg/d, 90 days
No. of animals per sex per dose:
20
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 3 000 mg/kg bw
Mortality:
One substance related death (1/20) was reported at the 3000 mg/kg bw/day dose level.

Applicant's summary and conclusion

Executive summary:

Conclusion:

The acute dermal LD50 is considered to be > 3000 mg/kg bw in the rat, because low mortality (1/20 animals) was seen only in the high dose group receiving 3000 mg/kg bw/day in a dermal 90-day study conducted according to OECD TG 411 and under GLP using male and female Wistar rats (BASF; 1985).