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Registration Dossier
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EC number: 200-842-0 | CAS number: 75-12-7
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- sub-chronic toxicity: other route
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Summary report: no detailed information, secondary literature; route of application not relevant for humans.
Data source
Reference
- Reference Type:
- publication
- Title:
- Etude toxicologique de la formamide et de ses dérivés N-Méthylés et N-Ethylés.
- Author:
- Chanh PH, Xuong ND, Azum-Gelade M-C
- Year:
- 1 971
- Bibliographic source:
- Thérapie 26, 409-424.
Materials and methods
- Principles of method if other than guideline:
- Method: other: according to Caujolle, F. et al.: Arzneimittelforschung 20: 1242-1246
- GLP compliance:
- no
Test material
- Reference substance name:
- Formamide
- EC Number:
- 200-842-0
- EC Name:
- Formamide
- Cas Number:
- 75-12-7
- Molecular formula:
- CH3NO
- IUPAC Name:
- formamide
- Details on test material:
- TS-Freetext:
formamide; no data on purity of the compound
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Duration of treatment / exposure:
- 7 weeks
- Frequency of treatment:
- once daily, 5 d/wk
Doses / concentrations
- Remarks:
- Doses / Concentrations:
150 mg/kg
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Post-exposure period: 24 h
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
Depression of body weight gain, leukocytosis, elevated SGOT
and SGPT in blood. No microscopic histological changes in
various tissues.
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