Triethylamine

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

01. Oct 1956 - 26. Oct 1956

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well documented report which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1960

Report date:

1960

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Deviations:

yes

Remarks:

two animals were tested

Principles of method if other than guideline:

Method: BASF-Test. Two animals were treated for 1, 5, 15 min and 20 hours using occlusive conditions. An application site of 2.5x2.5 cm was covered with the liquid test substance. After the application time (1, 5, 15 min) the skin was washed with Lutrol (50%). The animals were observed for 8 days and skin changes were recorded daily.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Triethylamine

EC Number:

204-469-4

EC Name:

Triethylamine

Cas Number:

121-44-8

Molecular formula:

C6H15N

IUPAC Name:

triethylamine

Details on test material:

- Name of test material (as cited in study report): Triethylamin

Test animals

Species:

rabbit

Strain:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 2.44 kg and 2.39 kg

Test system

Type of coverage:

occlusive

Preparation of test site:

not specified

Vehicle:

unchanged (no vehicle)

Controls:

other: untreated skin site of the same animal

Duration of treatment / exposure:

1, 5 or 15 min

Observation period:

26 days

Number of animals:

2

Results and discussion

In vivo

Results

Irritation parameter:

other: Irritation

Basis:

mean

Time point:

other: 24 h - 48 h - 72 h

Reversibility:

not fully reversible within: 26 days

Remarks on result:

other: 1 min of exposure caused full thickness necrosis

Any other information on results incl. tables

1 min application: marked edema and hemorrhagic areas on the day of application which remained almost unchanged for 1 week. At the end of observation period of 26 days scar formation was observed.

5 min and 15 min application: red-brown necrosis of leather-like consistency on the day of application which developed to hard crusts on day 8. After 3 weeks scar formation was observed.

A 20% preparation in olive oil was also tested. The skin effects were less pronounced.

Applicant's summary and conclusion

Interpretation of results:

corrosive

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

Triethylamine is corrosive to the rabbit skin.

Executive summary:

The BASF test was used to assess irritating potential of triethylamine. The conduction of the study was similar to the OECD Guideline 404. The test material caused marked edema with necrosis. The effects occured after 1 min of exposure.