Registration Dossier
Registration Dossier
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EC number: 200-262-8 | CAS number: 56-23-5
Additional ecotoxological information
Administrative data
- Endpoint:
- additional ecotoxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Insufficient information for reliability evaluation
Data source
Reference
- Reference Type:
- publication
- Title:
- Histoenzymological effects of carbon tetrachloride on the small intestine of a teleost fish, Heteropneustes fossilis
- Author:
- Singh S.P.
- Year:
- 2 001
- Bibliographic source:
- Geobios 29: 191-192, 2002
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Carbon tetrachloride
- EC Number:
- 200-262-8
- EC Name:
- Carbon tetrachloride
- Cas Number:
- 56-23-5
- Molecular formula:
- CCl4
- IUPAC Name:
- tetrachloromethane
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
This study was conducted to analyse the intestinal histochemistry of fishes exposed to CTC.
Adult healthy specimens were collected from water reservoirs of Jodhpur region (India).
Live fishes were dissected and small interstine fixed in neutral chilled formalin for 8 - 12 h. Afterwards, sections were cut and processed for the demonstration of alkaline phosphatase. Similarly, some specimens were administrated 1 ml of CTC mixture in paraffin and their small intestine part was fixed as described above. Sections were cut and processed for localization of phosphatase activity.
Results:
In CTC -fishes, no marked changes in the localization of phosphatase as well as its intensity in villi were observed. Tips of villi were highly suscetible to the toxicity induced by CTC resulting in the rupture and progressive erosion of brush borders extending inwards. Intestinal glands remained unaffected.
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