Registration Dossier
Registration Dossier
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EC number: 203-808-3 | CAS number: 110-85-0
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: STudy perfomred according to guideline and under GLP.
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Protocol EU Off. Journal L133, 30 , pp118-122
- Deviations:
- yes
- Remarks:
- Reference compound
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- Stock solution 25.2 g/l was titrated to neutral pH
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 30 min
- Test temperature:
- 20°C
- pH:
- 7.4 - 7.8
- Nominal and measured concentrations:
- 0, 20, 60, 180, 540, 1620 mg/l nominal
- Reference substance (positive control):
- yes
- Remarks:
- 2, 4, 5-trichlorophenol
- Duration:
- 30 min
- Dose descriptor:
- other: EC20
- Effect conc.:
- > 1 600 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 30 min
- Dose descriptor:
- NOEC
- Effect conc.:
- 540 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Results with reference substance (positive control):
- EC50 is within prescribed range 5- 30 mg/l
- Validity criteria fulfilled:
- yes
- Conclusions:
- Activated sludge respiration inhibition NOEC (30 min) is 540 mg/l.
- Executive summary:
In an Activated sludge respiration inibition test, according to EU guideline 30 min NOEC for respiration inhibition was 540 mg/l. The tested concentrations were 0, 20, 60, 180, 540, 1620 mg/l nominal. EC20 was >1600 mg/l
Reference
Description of key information
No EC50 value could be determined in an activated sludge respiration inhibition test. The EC20 was 1620 mg/L and the NOEC 540 mg/L.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 540 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
