Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 210-478-4 | CAS number: 616-38-6
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Remarks:
- Study in Chinese (brief english summary incl. several tables)
Data source
Reference
- Reference Type:
- publication
- Title:
- Mutagenicity of Methyl Tertiary-Butyl Ether, Anhydrous Ethanol and Dimethyl Carbonate
- Author:
- Song C, Gao X, Cheng C, Liu K, Zhou L & Zhao C (2004)
- Year:
- 2 004
- Bibliographic source:
- J Tianjin University 37, 678 - 681
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 483 (Mammalian Spermatogonial Chromosome Aberration Test)
- GLP compliance:
- not specified
- Type of assay:
- chromosome aberration assay
Test material
- Reference substance name:
- Dimethyl carbonate
- EC Number:
- 210-478-4
- EC Name:
- Dimethyl carbonate
- Cas Number:
- 616-38-6
- Molecular formula:
- C3H6O3
- IUPAC Name:
- dimethyl carbonate
- Test material form:
- other: liquid
- Details on test material:
- not further specified
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
-Weight at study initiation: 25-30 g
ENVIRONMENTAL CONDITIONS
-Temperature (°C): 18-22
-Humidity (%): 43-70
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not further specified
- Details on exposure:
- not further specified
- Duration of treatment / exposure:
- not further specified
- Frequency of treatment:
- single oral dosing
- Post exposure period:
- not further specified
Doses / concentrations
- Remarks:
- Doses / Concentrations: 0, 0.99, 1.99 or 3.97 g/kg bw
- No. of animals per sex per dose:
- 5 m
- Control animals:
- yes
- Positive control(s):
- yes
Examinations
- Tissues and cell types examined:
- 500 metaphases per group
- Details of tissue and slide preparation:
- not further specified
- Evaluation criteria:
- according to Guideline
- Statistics:
- yes
Results and discussion
Test results
- Key result
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- In this in vivo cytogenetic test for detection of chromosome aberrations in spermatogonial mitoses, 5 male mice were dosed once orally with 0, 0.99, 1.99 or 3.97 g/kg bw of dimethyl carbonate. The results of this study gave no indications for an increase in chromosome aberrations.
- Executive summary:
In this in vivo cytogenetic test for detection of chromosome aberrations in spermatogonial mitoses, 5 male mice were dosed once orally with 0, 0.99, 1.99 or 3.97 g/kg bw of dimethyl carbonate. The results of this study gave no indications for an increase in chromosome aberrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
