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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No GLP study. Documentation insufficient for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Principles of method if other than guideline:
No data
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Biphenyl
EC Number:
202-163-5
EC Name:
Biphenyl
Cas Number:
92-52-4
Molecular formula:
C12H10
IUPAC Name:
1,1'-biphenyl
Details on test material:
- Name of test material (as cited in study report): biphenyl

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Type of coverage:
not specified
Vehicle:
corn oil
Details on dermal exposure:
no data
Duration of exposure:
24h
Doses:
5010 and 7940 mg/kg
No. of animals per sex per dose:
1 female for dose of 5010 mg/kg
1 male and 1 female for dose of 7940 mg/kg
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 010 mg/kg bw

Applicant's summary and conclusion

Conclusions:
The dermal LD50 after 24 hours of exposure to biphenyl is greater than 5010 mg/kg bw in New-Zealand albino rabbits.