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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No GLP. Documentation insufficient for assessment of reliability.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Principles of method if other than guideline:
No data
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Biphenyl
EC Number:
202-163-5
EC Name:
Biphenyl
Cas Number:
92-52-4
Molecular formula:
C12H10
IUPAC Name:
1,1'-biphenyl
Details on test material:
- Name of test material (as cited in study report): biphenyl

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
no data

Test system

Type of coverage:
not specified
Preparation of test site:
other: intact and abraded skin
Vehicle:
unchanged (no vehicle)
Controls:
other: Intact skin served as a control
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g (moistened with water)
Duration of treatment / exposure:
24h
Observation period:
up to 10 days
Number of animals:
6
Details on study design:
no data

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Remarks:
for 24 and 72 hours
Time point:
other: 24 h, 72 h
Score:
0.3
Max. score:
8
Irritant / corrosive response data:
Skin flaked off in seven to ten days.
Other effects:
Slight defatting effect. There was no injury in depth.

Applicant's summary and conclusion

Conclusions:
Biphenyl was not irritating after 24 hours of exposure to New Zealand albino rabbit skin (0.5 gram applied as ground sample moistened with water). Slight defatting effect - skin flaked off in seven to ten days. There was no injury in depth.