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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1981
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Tocicity quantitative structure-activity relationships of colchicine
Author:
Frank R. Quinn, Zohar Neiman, and John A. Beisler
Year:
1981
Bibliographic source:
J.Med.Chem. 1981, 24, 636-639

Materials and methods

Principles of method if other than guideline:
Day five toxicities.
GLP compliance:
not specified
Remarks:
not reported

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
Swiss
Sex:
female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Doses:
not reported
No. of animals per sex per dose:
4/dose/mouse
Control animals:
no

Results and discussion

Applicant's summary and conclusion

Conclusions:
The LD50 evaluated according to the study was 1mg/kg.
Executive summary:

The LD50 evaluated according to the study was 1mg/kg.

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