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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2005-09-15 to 2005-09-23
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: OECD Guidelines for Testing Chemicals. Test Guideline No. 105, Paris, 1981
Deviations:
not specified
Qualifier:
according to guideline
Deviations:
not specified
Principles of method if other than guideline:
A study to determine the solubility of the sample of Sodium metabisulphite in six different organic solvents by adding 5 mL of each solvent to 5 mL of an acidified methanolic solution, and then adding dropwise on iodine solution prepared and diluted in methanol.
GLP compliance:
yes (incl. QA statement)
Medium:
methanol
Solubility:
62 g/L
Temp.:
20 °C
Remarks on result:
other: solubility measured at the plateau, after shaking overnight at room temperature
Medium:
toluene
Solubility:
< 0.01 g/L
Temp.:
20 °C
Remarks on result:
other: mean value of 6 flasks
Medium:
acetone
Solubility:
< 0.01 g/L
Temp.:
20 °C
Remarks on result:
other: mean value of 6 flasks
Medium:
ethyl acetate
Solubility:
< 0.01 g/L
Temp.:
20 °C
Remarks on result:
other: mean value of 6 flasks
Medium:
other: n-hexane
Solubility:
< 0.01 g/L
Temp.:
20 °C
Remarks on result:
other: mean value of 6 flasks
Medium:
other: dichloromethane
Solubility:
< 0.01 g/L
Temp.:
20 °C
Remarks on result:
other: mean value of 6 flasks
Test substance stable:
yes
Details on results:
No detailed information about the test-temperature are reported. However, tests were performed at room temperature; therefore a temperature of 20°C is entered in the respective subfields.
No further details are given.
Conclusions:
From the experimental data obtained it can be concluded that the solvent solubility of the sample of Sodium metabisulphite technical product is <0.01 g/L for five tested solvents (toluene, dichloromethane, n-hexane, acetone, ethyl acetate).
For the methanol, a solubility plateau is reached at 62 g/L after overnight shaking.
Executive summary:

The study was conducted to determine the solubility of the sample of Sodium metabisulphite in six different organic solvents by adding 5 mL of each solvent to 5 mL of an acidified methanolic solution, and then adding dropwise on iodine solution prepared and diluted in methanol. From the experimental data obtained it can be concluded that the solvent solubility of the sample of Sodium metabisulphite technical product is <0.01 g/L for five tested solvents (toluene, dichloromethane, n-hexane, acetone, ethyl acetate).

For the methanol, a solubility plateau is reached at 62 g/L after overnight shaking.

Description of key information

From the experimental data obtained it can be concluded that the solvent solubility of the sample of Sodium metabisulphite technical product is <0.01 g/L for five tested solvents (toluene, dichloromethane, n-hexane, acetone, ethyl acetate). For the methanol, a solubility plateau is reached at 62 g/L after overnight shaking.

Key value for chemical safety assessment

Additional information

From the experimental data obtained it can be concluded that the solvent solubility of the sample of Sodium metabisulphite technical product is < 0.1 g/L for five tested solvents (toluene, dichloromethane, n-hexane, acetone, ethyl acetate). For the methanol, a solubility plateau is reached at 62 g/L after overnight shaking.