Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 234-319-3 | CAS number: 11097-59-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
Read across from the RIVM decision from 23 October 2007(BMS071023.03) for Aluminium-magnesium-zinc-carbonate-hydroxide (EC 423-570-6).
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 605 mg/kg bw/day
Additional information
Based on the RIVM decision from October 23, 2007 (BMS071023.03) for analogue Alcamizer P93 (Aluminium-magnesium-zinc-carbonate-hydroxide, EC no. 423-570-6), the available data for the aluminium ion (NOAEL AL3+ >52 mg/kg bw/d) and the Al content of the registered substance (8.6%) were used to calculate the NOAEL for Magnesium-aluminium-hydroxide-carbonate. The same approach as for Alcamizer P93 was used to derive the endpoint, i.e. Al-NOAEL *100/Al content. In the RIVM decision, magnesium ions are stated to be not toxic to fertility.
Short description of key information:
NOAEL 605 mg/kg bw/d (in analogy to RIVM decision for Alcamizer P93, dated 23 October 2007, BMS071023.03)
Effects on developmental toxicity
Description of key information
NOAEL 151 mg/kg bw/d (in analogy to RIVM decision for Alcamizer P93, dated 23 October 2007, BMS071023.03)
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 151 mg/kg bw/day
Additional information
RIVM decision for Alcamizer P93, dated 23 October 2007, BMS071023.03)
Based on the RIVM decision from October 23, 2007 (BMS071023.03) for analogue Alcamizer P93 (Aluminium-magnesium-zinc-carbonate-hydroxide, EC no. 423-570-6), the available data for the aluminium ion (NOAEL AL3+ <13 mg/kg bw/d) and the Al content of the registered substance (8.6%) were used to calculate the NOAEL for Magnesium-aluminium-hydroxide-carbonate. The same approach as for Alcamizer P93 was used to derive the endpoint, i.e. Al-NOAEL *100/Al content resulting in a NOAEL of 605 mg/kg bw/d for fertility and a NOAEL of 151 mg/kg bw/d for developmental toxicity. The substance is not teratogenic.
Justification for classification or non-classification
In the absence of effects on fertility or developmental toxicity for the analogues, no classification is needed for Magnesium-Aluminium-Hydroxide-Carbonate.
Additional information
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