Registration Dossier

Administrative data

Description of key information

In a reproduction study pregnant rats were exposed to the test substance in diet (0, 0.1, 0.5 and 1.0% ). After weaning their offspring was treated until day 43. Effects on locomotor activity and brain levels of noradrenaline, dopamine and serotonine of the offspring were determined at specific intervals during the test period (interim kills where necessary).

No effects of the test substance was reported in this study

Key value for chemical safety assessment

Effect on neurotoxicity: via oral route

Endpoint conclusion
Dose descriptor:
NOAEL

Additional information

A NOAEL for the offspring cannot be expressed as mg/kg bw, as only information on dietary exposure is available.

The NOAEL in diet is 1% (10000 mg/kg diet).

Justification for classification or non-classification

No effects were reported either in parental animals or in offspring.