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EC number: 232-304-6 | CAS number: 8002-26-4 A complex combination of tall oil rosin and fatty acids derived from acidulation of crude tall oil soap and including that which is further refined. Contains at least 10% rosin.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 35.3 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 5
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 35.3 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 5
- Modified dose descriptor starting point:
- NOAEC
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 10 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 5
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 10 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 5
- Modified dose descriptor starting point:
- NOAEL
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
For the purposes of determining a Derived No Effect Level, a conservative approach is taken in which, as a worst case, the 2-year NOAEL >200 mg/kg/ day is used to represent the toxicity of the whole substance for repeated dose systemic toxicity in all cases. In the absence of any findings indicative of reproductive or developmental effects for any of the substances tested, DNELs for these endpoints cannot be quantified. No short-term peak exposures to DTO are expected under normal conditions of use, so long-term DNELs are also protective for short-term exposures. The substance is not classified as skin irritant, eye irritant or sensitising.
The oral route is not considered for workers, since oral exposure will not occur during normal handling and use of DTO.
Table 5.16: Corrected dose descriptor(s) per endpoint and endpoint-specific DNEL(s)/DMEL(s) for workers
Endpoint |
Route |
Most relevant quantitative dose descriptor (appropriate unit) |
Corrected dose descriptor (appropriate unit) |
Overall AF applied |
Endpoint-specific DNEL/DMEL (appropriate unit) |
|||
Local |
Systemic |
Local |
Systemic |
Local |
Systemic |
|||
Repeated dose toxicity sub-acute/ sub-chronic/ chronic |
oral |
NA |
NOAEL >200 mg/kg/d |
NA |
NOAEL >50 mg/kg/d |
NA |
NA |
NA |
dermal |
NA |
No data |
NA |
NOAEL >50 mg/kg/d |
5 |
NA |
>10 mg/kg/d |
|
inhalation |
NA |
No data |
NA |
NOAEC >177 mg/m3 |
5 |
NA |
>35.3 mg/m3 |
Table 5.17: DN(M)ELs for workers
Exposure pattern |
Route |
Descriptors |
DNEL |
Most sensitive endpoint |
Acute - systemic effects |
Dermal |
Not quantifiable |
- |
No effects |
Inhalation |
Not quantifiable |
- |
No effects |
|
Oral |
Not quantifiable |
- |
No effects |
|
Acute - local effects |
Dermal |
Not quantifiable |
|
No effects |
Inhalation |
Not quantifiable |
- |
No effects |
|
Long-term - systemic effects |
Dermal |
DNEL |
>10 mg/kg/d |
Repeated-dose toxicity |
Inhalation |
DNEL |
>35.3 mg/m3 |
Repeated-dose toxicity |
|
Long-term – local effects |
Dermal |
Not quantifiable |
- |
No effects |
Inhalation |
Not quantifiable |
- |
No effects |
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 8.7 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 10
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 8.7 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 10
- Modified dose descriptor starting point:
- NOAEC
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 10
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 10
- Modified dose descriptor starting point:
- NOAEL
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 10
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 10
- Modified dose descriptor starting point:
- NOAEL
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
For the purposes of determining a Derived No Effect Level, a conservative approach is taken in which, as a worst case, the 2-year NOAEL >200 mg/kg/ day is used to represent the toxicity of the whole substance for repeated dose systemic toxicity. In the absence of any findings indicative of reproductive or developmental effects, DNELs for these endpoints cannot be quantified.
No short-term peak exposures to DTO are expected under normal conditions of use, so long-term DNELs are also protective for short-term exposures.
DTO does not have any local irritant effects and is not a skin sensitiser.
DTO is not classified for acute toxicity, irritation, sensitisation, repeated-dose toxicity, carcinogenicity, mutagenicity, reproductive or developmental toxicity. Findings in repeated-dose dietary studies in rats were minor and related mainly to unpalatability of the test diet, rather than showing evidence of systemic toxicity. However, the available data have been used to determine indicative long-term DNEL values, as a worst-case.There were no effects for reproductive or developmental endpoints; therefore it is not possible to quantify DNELs for reproductive or developmental toxicity.
Table 5.18: DN(M)ELs for the general population
Exposure pattern |
Route |
Descriptors |
DNEL/DMEL (appropriate unit) |
Most sensitive endpoint |
Acute - systemic effects |
Dermal |
Not quantifiable |
- |
No effects |
Inhalation |
Not quantifiable |
- |
No effects |
|
Oral |
Not quantifiable |
- |
No effects |
|
Acute - local effects |
Dermal |
Not quantifiable |
- |
No effects |
Inhalation |
Not quantifiable |
- |
No effects |
|
Long-term - systemic effects |
dermal |
DNEL |
>5 mg/kg/d |
Repeated-dose toxicity |
Inhalation |
DNEL |
>8.7 mg/m3 |
Repeated-dose toxicity |
|
oral |
DNEL |
>5 mg/kg/d |
Repeated-dose toxicity |
|
Long-term – local effects |
Dermal (mg/cm2) |
Not quantifiable |
- |
No effects |
Inhalation (mg/m3) |
Not quantifiable |
- |
No effects |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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