Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 202-613-0 | CAS number: 97-86-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Acute oral toxicity, rat, LD50=9590 mg/kg (Sterner and Stiglic, 1977)
Acute dermal toxicity > 5000 mg/kg (category read-across)
Acute inhalation toxicity, LT50 290 min at 29.74 mg/L (Lawrence et al. 1974)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 9 590 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 29 740 mg/m³ air
Additional information
Data availability
For i-BMA a study is available for acute oral as well as acute inhalation toxicity. There are no valid data for dermal toxicity, but only two acute endpoints are required. By analogy to the isomer n-BMA it can be concluded that i-BMA is predicted to be of low acute dermal toxicity.
Oral route
In a study following an FDA guideline from 1959, which is equivalent to an OECD 401 guideline study, i-BMA was administered at doses ranging from 8880 to17760 mg/kg by intragastric intubation to fasted male and female rats (Sterner and Stiglic, 1977). Except for local effects at the site of first contact, haemorrhage in the intestinal tract, no target organ was identified. The LD50 was determined to be 9590 mg/kg, when administered as a single oral dose. Hence, the available data indicate that i-BMA is of low acute oral toxicity.
Inhalation route
In a screening study using male ICR mice the exposure time was determined which was lethal to half of the exposed animals (LT50; Lawrence et al. 1974).At the limit concentration of 29.74 mg/L (5029 ppm) average survival time was 290 min. Hence, this dose is also comparable to an LC50 in a standard inhalation test.In an inhalation study (Jones, 2002) in F344 rats, using specialist histopathology techniques to study the nasal tissues, isobutyl methacrylate did not produce lesions in the olfactory region of the nasal cavity, the target for methacrylate esters, following exposure at 200 ppm for 6 hrs. The available data indicate that all members of the category, i-BMA included, are of low acute inhalation toxicity. The vapour pressure of the esters drops markedly across the category such that already in the case of the butyl esters the observed toxicity is above the saturated vapour pressure as indicated by the fact that the studies were performed with mixtures of vapour and mist.
Dermal route
There is also a early pre-guideline studies of limited reliability available in guinea pigs for i-BMA that indicate low acute dermal toxicity. By analogy to other esters in the category, low dermal toxicity of i-BMA is predicted.
Justification for classification or non-classification
According to the available data and CLP as well as US-GHS(2009) criteria, no classification is warranted for acute toxicity.
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