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EC number: 219-784-2 | CAS number: 2530-83-8
In a good quality one-generation reproductive toxicity study (reliability score 1) conducted to OECD Test Guideline 415 and GLP, the parental and reproductive NOAELs for [3-(2,3-epoxypropoxy)propyl]trimethoxysilane were = 1000 mg/kg bw/d, in rats. Treatment with the test substance resulted in signs of discomfort after dosing (noted for P females from early /mid gestation onwards), decreased body weight gain of males, and increased absolute and relative liver and kidney weights in P males and females. Histopathology revealed effects on livers and kidneys of males.
Please see attached document for result tables.
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