Registration Dossier
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EC number: 215-213-6 | CAS number: 1313-96-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
8.1.1. Summary and overall conclusions on PBT or vPvB properties
Taking into account all available data on biotic and abiotic degradation, bioaccumulation and toxicity it can be stated that diniobium pentaoxide is neither toxic nor does it accumulate in living being, but it is judged to be very persistent in the environment. Since not all three criteria for persistence, bioaccumulation and toxicity are fulfilled,diniobium pentaoxideis judged not to be a PBT substance.
8.1.2. PBT/vPvB criteria and justification
Persistence Assessment
According to the “Guidance on information requirements and chemical safety assessment Chapter R.11: PBT Assessment” (ECHA, 2008) the screening assessment for persistence should be based on all available data from biodegradation studies, abiotic degradation studies and estimation models.
Sincediniobium pentaoxideis an inorganic substance biodegradation cannot be assessed. Abiotic degradation is also not expected to occur. The substance is stable in water and does not hydrolyze. It is not volatile and does not enter into the atmosphere hence a reaction with atmospheric molecules, like OH radicals and a consequently degradation is impossible.Diniobium pentaoxidemetal is considered to remain stable in nature and thus to be persistent (P).
Bioaccumulation Assessment
Diniobium pentaoxideis insoluble in water (< 0.5 μg/L) and not bioavailable to aquatic species. As an inorganic substance without any bioavailability, Nb2O5 cannot be metabolized. Under physiological conditions,diniobium pentaoxidecannot be absorbed via skin or gastrointestinal tract. Even in case of absorption via the oral route and ingested, Nb will be eliminated via faeces without prior absorption. Thus, there is no potential for bioaccumulation anddiniobium pentaoxideis considered neither to be bioaccumulative (B) nor very bioaccumulative (vB).
Toxicity Assessment
According to the “Guidance on information requirements and chemical safety assessment Chapter R.11: PBT Assessment” (ECHA, 2008) the PBT assessment for toxicity must be based on NOEC values for marine or freshwater organisms, and on considerations of the classification of the substance as CMR and/or chronic toxic to humans.
No data is available on aquatic organisms, carcinogenicity and toxicity to reproduction. Sincediniobium pentaoxideis insoluble in water and not bioavailable via any route it is not considered to cause any adverse effect neither to animals nor to humans. An acute dermal study withdiniobium pentaoxideshowed no effect,diniobium pentaoxideis neither irritant to skin nor to the eye and was found to be not sensitizing. Three studies on genetic toxicity showed thatdiniobium pentaoxideis not mutagenic. Based on these datadiniobium pentaoxide is considered not to be toxic (T).
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