Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
5 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
5 450 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

Acute dermal toxicity was tested in rats. The LD50 was greater than 2000 mg/kg bw. Due to the chemical properties of diniobium pentaoxide, it can be predicted that oral bioavailability of niobium metal is nil.

The oral LD50 is thus estimated to be greater than 5000 mg/kg bw and the inhalation LC50 is estimated to be greater than 5000 mg/m³ air.

Justification for classification or non-classification

Dermal and oral LD50 values are greater than 2000 and 5000 mg/kg bw, respectevely. Inhalation LC50 is greater than 5000 mg/m³ air. No classification for acute lethal effects is necessary.