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Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
repeated dose toxicity: other route
Remarks:
other: migrated dataset
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: administration of the testsubstance not relevant for the human situation

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Pathology and Toxicology of Repeated Doses of Hydrazine and 1,1-Dimethylhydrazine in Monkeys and Rats.
Author:
Patrick RL and Back KC
Year:
1965
Bibliographic source:
Ind. Med. Surg. 34, 430-435.
Reference Type:
other: abstract
Title:
Hydrazine
Author:
Patrick RL
Year:
1964
Bibliographic source:
Technical Documentation Report No AMRL-TOR-64-43

Materials and methods

Principles of method if other than guideline:
Method: other: migrated dataset
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
IUPAC Name:
Automatically generated during migration to IUCLID 6, no data available
Details on test material:
IUCLID4 Test substance: other TS : migrated dataset

TS-Freetext:
practical grade

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other:
Duration of treatment / exposure:
up to 5 weeks
Frequency of treatment:
once daily, 5 days per week
Doses / concentrations
Remarks:
Doses / Concentrations:
10 or 20 mg/kg
No. of animals per sex per dose:
migrated dataset
Control animals:
yes, concurrent vehicle
Details on study design:
Post-exposure period: no

Results and discussion

Effect levels

Dose descriptor:
dose level:
Effect level:
>= 10 - <= 20 mg/kg bw/day
Sex:
male
Basis for effect level:
other: rat

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Dose-dependent weight loss; mortality in high dose group 10/25 (8-21 injection), signs of toxicity were weakness, lethargy, lowered food intake, partial epilation, convulsions in 2 rats; in both groups hematocrit value lowest after 13 injections; serum glutamic oxaloacetic transaminase tended to increase after 3 injections; pulmonary congestion and edema in 4 rats and hepatic lipidosis in 7 rats of the high dose group.

Applicant's summary and conclusion