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EC number: 270-695-5 | CAS number: 68476-55-1
Toxicity to terrestrial arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to terrestrial arthropods: long-term
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- PETROTOX is a well documented and peer reviewed model that is widely used across the petrochemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions. See Attached Justification.
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- - Software tool(s) used including version:
See Field 'Attached justification'
- Model(s) used:
See Field 'Attached justification'
- Model description: See Field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification' - GLP compliance:
- not specified
- Specific details on test material used for the study:
- HC Block Type Carbon Number Concentration (%w/w)
MoAr 6 0.960
n-CC5 5 14.35
n-P 4 2.9
n-P 5 33.49
n-P 6 0.96
i-P 5 33.49
i-P 6 12.9
i-Olefin 5 1.0
Total 100.00
The constituents that could fit in more than one HC block, or that did not fit in any specific block, were placed in a relevant block that presented the highest toxicity. - Analytical monitoring:
- not required
- Test organisms (species):
- Folsomia candida
- Animal group:
- Collembola (soil-dwelling springtail)
- Study type:
- other: QSAR
- Total exposure duration:
- 28 d
- Reference substance (positive control):
- no
- Remarks:
- Not required
- Duration:
- 28 d
- Dose descriptor:
- other: LL50
- Effect conc.:
- 68.6 mg/kg soil dw
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR prediction
- Basis for effect:
- mortality
- Remarks on result:
- other: QSAR predicted value
- Duration:
- 28 d
- Dose descriptor:
- other: EL10
- Effect conc.:
- 13.1 mg/kg soil dw
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR prediction
- Basis for effect:
- reproduction
- Remarks on result:
- other: QSAR predicted value
- Validity criteria fulfilled:
- yes
- Conclusions:
- The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) for the UVCB substance were 68.6 and 13.1 mg/kg soil dw, respectively.
- Executive summary:
The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) for the UVCB substance forFolsomia candida were 68.6 and 13.1 mg/kg soil dw, respectively. The model used for the calculations was the PETROTOX v4.0 model. PETROTOX is a well-documented and peer reviewed model that is widely used across the chemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.
- Endpoint:
- toxicity to terrestrial arthropods: long-term
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- PETROTOX is a well documented and peer reviewed model that is widely used across the petrochemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions. See Attached Justification.
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- - Software tool(s) used including version:
See Field 'Attached justification'
- Model(s) used:
See Field 'Attached justification'
- Model description: See Field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification' - GLP compliance:
- not specified
- Specific details on test material used for the study:
- HC Block Type Carbon Number Concentration (%w/w)
MoAr 6 0.669
n-CC5 5 3.29
n-CC5 6 17.2
n-CC5 7 1.94
n-CC6 6 3.63
n-CC6 7 0.154
n-Olefin 6 0.138
i-Olefin 6 0.361
i-Olefin 7 0.188
n-P 4 0.527
n-P 5 1.40
n-P 6 25.2
n-P 7 0.505
i-P 5 0.437
i-P 6 20.3
i-P 7 23.5
Total 99.5
The constituents that could fit in more than one HC block, or that did not fit in any specific block, were placed in a relevant block that presented the highest toxicity. - Analytical monitoring:
- not required
- Test organisms (species):
- Folsomia candida
- Animal group:
- Collembola (soil-dwelling springtail)
- Study type:
- other: QSAR
- Total exposure duration:
- 28 d
- Reference substance (positive control):
- no
- Remarks:
- Not required
- Duration:
- 28 d
- Dose descriptor:
- other: LL50
- Effect conc.:
- 86.5 mg/kg soil dw
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR prediction
- Basis for effect:
- mortality
- Remarks on result:
- other: QSAR predicted value
- Duration:
- 28 d
- Dose descriptor:
- other: EL10
- Effect conc.:
- 16.6 mg/kg soil dw
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR prediction
- Basis for effect:
- reproduction
- Remarks on result:
- other: QSAR predicted value
- Validity criteria fulfilled:
- yes
- Conclusions:
- The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) for the UVCB substance were 86.5 and 16.6 mg/kg soil dw, respectively.
- Executive summary:
The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 for the UVCB substance for Folsomia candida were 86.5 and 16.6 mg/kg soil dw, respectively. The model used for the calculations was the PETROTOX v4.0 model. PETROTOX is a well-documented and peer reviewed model that is widely used across the chemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.
- Endpoint:
- toxicity to terrestrial arthropods: long-term
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- PETROTOX is a well documented and peer reviewed model that is widely used across the petrochemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions. See Attached Justification.
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- - Software tool(s) used including version:
See Field 'Attached justification'
- Model(s) used:
See Field 'Attached justification'
- Model description: See Field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification' - GLP compliance:
- not specified
- Specific details on test material used for the study:
- HC Block Type Carbon Number Concentration (%w/w)
MoAr 6 3.89
n-CC5 6 43.5
n-CC5 7 8.55
n-CC6 6 12.8
n-CC6 7 0.370
n-P 6 17.00
n-P 7 1.87
i-P 6 0.74
i-P 7 10.8
Total 99.5
The constituents that could fit in more than one HC block, or that did not fit in any specific block, were placed in a relevant block that presented the highest toxicity. - Analytical monitoring:
- not required
- Test organisms (species):
- Folsomia candida
- Animal group:
- Collembola (soil-dwelling springtail)
- Study type:
- other: QSAR
- Total exposure duration:
- 28 d
- Reference substance (positive control):
- no
- Remarks:
- Not required
- Duration:
- 28 d
- Dose descriptor:
- other: LL50
- Effect conc.:
- 82.6 mg/kg soil dw
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR prediction
- Basis for effect:
- mortality
- Remarks on result:
- other: QSAR predicted value
- Duration:
- 28 d
- Dose descriptor:
- other: EL10
- Effect conc.:
- 15.8 mg/kg soil dw
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR prediction
- Basis for effect:
- reproduction
- Remarks on result:
- other: QSAR predicted value
- Validity criteria fulfilled:
- yes
- Conclusions:
- The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) for the UVCB substance were 82.6 and 15.8 mg/kg soil dw, respectively.
- Executive summary:
The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) for the UVCB substance for Folsomia candida were 82.6 and 15.8 mg/kg soil dw, respectively. The model used for the calculations was the PETROTOX v4.0 model. PETROTOX is a well-documented and peer reviewed model that is widely used across the chemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.
- Endpoint:
- toxicity to terrestrial arthropods: long-term
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- PETROTOX is a well documented and peer reviewed model that is widely used across the petrochemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions. See Attached Justification.
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- - Software tool(s) used including version:
See Field 'Attached justification'
- Model(s) used:
See Field 'Attached justification'
- Model description: See Field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification' - GLP compliance:
- not specified
- Specific details on test material used for the study:
- HC Block Type Carbon Number Concentration (%w/w)
MoAr 6 0.960
n-CC5 5 56.8
n-CC5 6 0.5
n-P 5 4.10
n-P 6 4.08
i-P 5 3.86
i-P 6 29.7
Total 99.97
The constituents that could fit in more than one HC block, or that did not fit in any specific block, were placed in a relevant block that presented the highest toxicity. - Analytical monitoring:
- not required
- Test organisms (species):
- Folsomia candida
- Animal group:
- Collembola (soil-dwelling springtail)
- Study type:
- other: QSAR
- Total exposure duration:
- 28 d
- Reference substance (positive control):
- no
- Remarks:
- Not required
- Duration:
- 28 d
- Dose descriptor:
- other: LL50
- Effect conc.:
- 68.9 mg/kg soil dw
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR prediction
- Basis for effect:
- mortality
- Remarks on result:
- other: QSAR predicted value
- Duration:
- 28 d
- Dose descriptor:
- other: EL10
- Effect conc.:
- 13.2 mg/kg soil dw
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR prediction
- Basis for effect:
- reproduction
- Remarks on result:
- other: QSAR predicted value
- Validity criteria fulfilled:
- yes
- Conclusions:
- The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) for the UVCB substance were 68.9 and 13.2 mg/kg soil dw, respectively.
- Executive summary:
The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) for the UVCB substance for Folsomia candida were 68.9 and 13.2 mg/kg soil dw, respectively. The model used for the calculations was the PETROTOX v4.0 model. PETROTOX is a well-documented and peer reviewed model that is widely used across the chemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.
- Endpoint:
- toxicity to terrestrial arthropods: long-term
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- PETROTOX is a well documented and peer reviewed model that is widely used across the petrochemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions. See Attached Justification.
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- - Software tool(s) used including version:
See Field 'Attached justification'
- Model(s) used:
See Field 'Attached justification'
- Model description: See Field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification' - GLP compliance:
- not specified
- Specific details on test material used for the study:
- HC Block Type Carbon Number Concentration (%w/w)
MoAr 6 3.13
n-CC5 5 31.6
n-CC5 6 6.96
n-CC5 7 1.80
n-CC6 6 31.4
n-CC6 7 1.00
n-P 4 5.14
n-P 5 5.14
n-P 6 3.38
n-P 7 1.90
i-P 4 0.180
i-P 5 2.19
i-P 6 4.74
i-P 7 1.22
Total 99.7
The constituents that could fit in more than one HC block, or that did not fit in any specific block, were placed in a relevant block that presented the highest toxicity. - Analytical monitoring:
- not required
- Test organisms (species):
- Folsomia candida
- Animal group:
- Collembola (soil-dwelling springtail)
- Study type:
- other: QSAR
- Total exposure duration:
- 28 d
- Reference substance (positive control):
- no
- Remarks:
- Not required
- Duration:
- 28 d
- Dose descriptor:
- other: LL50
- Effect conc.:
- 70.7 mg/kg soil dw
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR prediction
- Basis for effect:
- mortality
- Remarks on result:
- other: QSAR predicted value
- Duration:
- 28 d
- Dose descriptor:
- other: EL10
- Effect conc.:
- 13.5 mg/kg soil dw
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR prediction
- Basis for effect:
- reproduction
- Remarks on result:
- other: QSAR predicted value
- Validity criteria fulfilled:
- yes
- Conclusions:
- The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) for the UVCB substance were 70.7 and 13.5 mg/kg soil dw, respectively.
- Executive summary:
The QSAR predicted 28-d LL50 (mortality) and 28-d EL10 (reproduction) for the UVCB substance for Folsomia candida were 70.7 and 13.5 mg/kg soil dw, respectively. The model used for the calculations was the PETROTOX v4.0 model. PETROTOX is a well-documented and peer reviewed model that is widely used across the chemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.
Referenceopen allclose all
Description of key information
The terrestrial toxicity was predicted by a QSAR, the PETROTOX v4.0 computer model. PETROTOX is a well-documented and peer reviewed model that is widely used across the chemicals industry. The substances of this category fit within the criteria of the model and there are no reservations about the validityof the model runs. The predicted 28-d LL50 (mortality) values for Folsomia candida ranged from 68.9 to 86.5 mg/kg soil dw. The predicted 28-d EL10 (reproduction) values for Folsomia candida ranged from 13.1 to 16.6 mg/kg soil dw.
Key value for chemical safety assessment
Additional information
| Species | CAS No. | EC No. | LL50 (mg/kg dw) | EL10 (mg/kg dw) |
| Folsomia candida | 92128-65-9 | 295-762-6 | 70.7 | 13.5 |
| Folsomia candida | 64742-49-0 | 265-151-9 | 82.6 | 15.8 |
| Folsomia candida | 64741-84-0 | 265-086-6 | 86.5 | 16.6 |
| Folsomia candida | 68476-55-1 | 270-695-5 | 68.9 | 13.2 |
| Folsomia candida | 102110-14-5 | 310-012-0 | 68.6 | 13.1 |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
