Registration Dossier
Registration Dossier
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EC number: 200-821-6 | CAS number: 74-90-8
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 7.9 mg/kg bw/day
- Study duration:
- chronic
- Species:
- rat
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
HCN was used as a fumigant in food consumed by rats for a two year experimental period. No evidence of carcinogenicity was observed in any of the organs examined in the exposed animals. Hydrogen cyanide is not carcinogenic under conditions of this study.
Additional information
Carworth Farms rats (10/sex/group) were fed diets fumigated with HCN for 2 years.The dietary concentrations were 100 and 300 mg/kg. The animals did not accept higher concentrations due to reduced palatability. Survival, body-weight gain, food intake, and clinical behaviour were not different between treated and control groups in the two year study. Absolute and relative organ weights were also comparable to controls. No treatment-related histopathological changes were observed in the organs examined. The NOAEL in this study was approximately 8.2 mg HCN/kg bw/d, or 7.9 mg CN ion/kg bw/d.
Justification for selection of carcinogenicity via oral route endpoint:
valid scientific study
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