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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Epidemiological data

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Administrative data

epidemiological data
Type of information:
other: review
Adequacy of study:
weight of evidence
Study period:
Articles from Jan 2000 to Aug 2020
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
There is no information given on quality criteria of study inclusion, however the review still gives a good overview of epidemiological studies concerning DMP

Data source

Reference Type:
The effects of phthalate ester exposure on human health: A review
Wei-Hsiang Chang, Samuel Herianto, Ching-Chang Lee, Hsin Hung, Hsiu-Ling Chen
Bibliographic source:
Science of the Total Environment 786 (2021) 147371

Materials and methods

Study type:
other: review
Endpoint addressed:
other: reproductive diseases, cardiovascular diseases, thyroid disorders, repsiratory diseases, diabetes, obesity, kidney diseases, neurological disorders
Test guideline
no guideline required
Principles of method if other than guideline:
The study authors attempt to review eight main health effects of phthalate exposure according to the most up-to-date studies.
GLP compliance:

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl phthalate
EC Number:
EC Name:
Dimethyl phthalate
Cas Number:
Molecular formula:
1,2-dimethyl benzene-1,2-dicarboxylate
Test material form:


Type of population:

Results and discussion

Any other information on results incl. tables

MMP (the main metabolite of DMP) was not associated with:

-anogenital distance in Japanese newborn (Suzuki, 2012) and in Taiwanese neweborn (Huang, 2009);

-coronary heart disease (Song, 2015);

-thicker carotid-artery intima and media thickness (which itself is associated with the prevalence of cardiovascular disease) in young adults and adolescents in Taiwan (Su, 2019).

A sum parameter of low molecular weight phthalate esters (including MMP) was associated with a lower nonverbal IQ score in children (van den Dries, 2020). However it is unclear if this is of direct relevance.

Higher MMP levels were associated with premature thelarche (Chou, 2009 and Zhang 2015), however the study population was very small with only 89 participants and the relevance is therefore unclear.

MMP was not associated with obesity in children (Xia, 2018). However in another study (Amin, 2018) MMP was associated with obesity in Iranian children. Further there was an association with obesity in Chinese males and females (Li, 2020) and DMP was associated with total cholesterol levels in Chinese serum (Zhang, 2018). The results are somehow inconsistent. However, since DMP is used in food packaging, a correlation (without causality) seems plausible.

Applicant's summary and conclusion