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EC number: 926-273-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
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- Flash point
- Auto flammability
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- Explosiveness
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- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
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- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
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- Nanomaterial surface chemistry
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- Endpoint summary
- Stability
- Biodegradation
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- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
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- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990/10/22-1990/11/06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to OECD 420 guideline. GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Hydrocarbons, C10-C13, aromatics, >1% naphthalene
- EC Number:
- 926-273-4
- Molecular formula:
- None available - not a single isomer - see remarks
- IUPAC Name:
- Hydrocarbons, C10-C13, aromatics, >1% naphthalene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan
- Age at study initiation: Approximately 9 - 10 weeks
- Weight at study initiation: Males (260-295 g), Females (201-228 g)
- Fasting period before study: approximately 16h
- Housing: individual
- Diet (e.g. ad libitum): Purina certified rodent chow, ad libitum
- Water (e.g. ad libitum): Automatic watering system, ad libitum
- Acclimation period: 7d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 40-70%
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- The test material MRD-90-884 was diluted in corn oil and administered at the appropriate dose levels by a single oral intubation via syringe and a no. 16 stainless steel straight, ball-tipped feeding needle.
- Doses:
- 500 mg/kg, 1500 mg/kg, 5000 mg/kg
- No. of animals per sex per dose:
- Male (5), Female (5); total animals (30)
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 1, 2, 4, and 6 h after dosing and once per day thereafter for a total of 14 days
Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- The means and standard deviations of the body weights and body weight changes were calculated. LD50 was calculated using the standard Litchfield-Wilcoxon technique with equal weighting of the data points.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 10 650 mg/kg bw
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 5 210 mg/kg bw
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 7 050 mg/kg bw
- Remarks on result:
- other: combined LD50
- Mortality:
- No mortality was observed in the 500 or 1500 mg/kg doses. In the 5000 mg/kg dose group, two males were found dead on day 2; two females were found dead on day 3, and a final female death noted on day 4.
- Clinical signs:
- other: No abnormal clinical in-life observations were noted for the majority of animals in either the 500 or 1500 mg/kg doses; only a single incidence ano-genital staining and a single oral/ocular discharge were noted. In the 5000 mg/kg group the most frequentl
- Gross pathology:
- No abnormal pathological observations were noted for the animals in either the 500 or 1500 mg/kg dosed groups. The animals that succumbed prior to study termination exhibited staining of the lungs and of the fur, abnormalities of the stomach and gastro-intestinal tract, liver discoloration and distension, and abnormal contents of the cecum and urinary bladder. Four of the five survivors in this group displayed no abnormalities, while the remaining animals exhibited alopecia.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 for males is 10650 mg/kg and the LD50 for female animals is 5210 mg/kg. The combined estimated LD50 (both sexes) is 7050mg/kg. This finding does not warrant classification as an acute oral toxicant under the new Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP).
- Executive summary:
The acute toxicity of MRD-90-884 was evaluated in rats via oral gavage at doses of 500 mg/kg, 1500 mg/kg, or 5000 mg/kg fasted body weight. Observations were made as to the nature, onset, severity, and duration of toxicological signs at 1, 2, 4, and 6 hours after dosing and once per day for a total of 14 days. Animals in the 500 or 1500 mg/kg dose groups survived the entire observational period and displayed a low incidence of clinical symptoms. Two males and three female animals in the 5000 mg/kg dosing group did not survive the study and died on days 2 - 4. The most frequently noted in-life clinical abnormalities were ano-genital staining, oral/nasal discharges, decreased appetite, hypoactivity, and prostration. Gross postmortem examination of the animals that succumbed prior to study termination revealed staining of the lungs and of the fur, and abnormalities of the stomach, gastro-intestinal tract, liver and bladder. The surviving animals displayed little or no abnormalities. The surviving animals had no observable abnormalities. It is estimated that the LD50 for males is 10650 mg/kg and the LD50 for female animals is 5210 mg/kg. The combined estimated LD50 (both sexes) is 7050mg/kg. This finding does not warrant classification as an acute oral toxicant under the new Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP).
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