Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Study period:
April 7, 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Dermal absorption estimated using modeling program (US EPA's Estimation Program Interface) recommended in the REACH Guidance.

Data source

Materials and methods

Principles of method if other than guideline:
Dermwin module (v1.43), EPI v3.20
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1'-(ethane-1,2-diyl)bis[pentabromobenzene]
EC Number:
284-366-9
EC Name:
1,1'-(ethane-1,2-diyl)bis[pentabromobenzene]
Cas Number:
84852-53-9
Molecular formula:
C14H4Br10
IUPAC Name:
1,2,3,4,5-pentabromo-6-[2-(2,3,4,5,6-pentabromophenyl)ethyl]benzene
Details on test material:
Dermal absorption was modeled based on DBDPEthane's chemical structure.
Radiolabelling:
no

Test animals

Species:
other: none
Strain:
other: not applicable
Sex:
not specified

Administration / exposure

Type of coverage:
other: not applicable
Vehicle:
other: not applicable
Duration of exposure:
not applicable
Doses:
not applicable
No. of animals per group:
not applicable
Control animals:
no

Results and discussion

Signs and symptoms of toxicity:
not specified
Dermal irritation:
not specified
Absorption in different matrices:
Dermal absorption of DBDPEthane is not expected. Dermwin v1.43 estimates dermal absorption of 3.2E-15 mg/cm2-event using Fick's first law of diffusion or 5.6E-9 mg/cm2-event using equations contained in the program.
Total recovery:
not applicable
Percutaneous absorption
Remarks on result:
other:

Applicant's summary and conclusion

Conclusions:
Dermal absorption of DBDPEthane is not expected. Dermwin v1.43 estimates dermal absorption of 3.2E-15 mg/cm2-event using Fick's first law of diffusion or 5.6E-9 mg/cm2-event using equations contained in the program. This is consistent with the high molecular weight and negligible solubility of DBDPEthane.
Executive summary:

Dermal absorption of DBDPEthane is not expected. Dermwin v1.43 estimates dermal absorption of 3.2E-15 mg/cm2-event using Fick's first law of diffusion or 5.6E-9 mg/cm2-event using equations contained in the program. This is consistent with the high molecular weight and negligible solubility of DBDPEthane.