Registration Dossier

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Administrative data

Description of key information

A reliable study available for acute oral toxicity of silver chloride is available (rat, LD50 > 5510 mg/kg bw). Similar acute oral toxicity studies with other silver substances (Ag metal, Ag2O, Ag2CO3 and Ag2SO4) all indicate low acute oral toxicity of silver compounds (all LD50>2000 mg/kg bw). These studies are included in this dossier for comparative reasons.
Testing for acute inhalation toxicity is scientifically unjustified for AgCl (see respective justification for waiving). Testing for acute dermal toxicity is scientifically not justified for AgCl, because of the low potential for any dermal penetration (see section on toxicokinetics) and the generally low acute, systemic toxicity.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for selection of acute toxicity – oral endpoint
Key study

Justification for selection of acute toxicity – inhalation endpoint
Waiving

Justification for selection of acute toxicity – dermal endpoint
Waiving

Justification for classification or non-classification

A reliable study available for acute oral toxicity of silver chloride is available (rat, LD50 > 5510 mg/kg bw). Similar acute oral toxicity studies with other silver substances (Ag metal, Ag2O, Ag2CO3 and Ag2SO4) all indicate low acute oral toxicity of silver compounds (all LD50>2000 mg/kg bw). Testing for acute inhalation toxicity is scientifically unjustified for AgCl (see respective justification for waiving).

Testing for acute dermal toxicity is scientifically not justified for AgCl, because of the low potential for any dermal penetration and the generally low acute, systemic toxicity.

In consequence, silver chloride does not require classification for acute toxicity endpoints.